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TLE1 transducin like enhancer of split 1 [ Gallus gallus (chicken) ]

Gene ID: 427450, updated on 3-Dec-2024

Summary

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Symbol
TLE1provided by CGNC
Full Name
transducin like enhancer of split 1provided by CGNC
Primary source
CGNC:9545
See related
Ensembl:ENSGALG00010015766
Gene type
protein coding
RefSeq status
MODEL
Organism
Gallus gallus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Orthologs
human all
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Genomic context

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See TLE1 in Genome Data Viewer
Location:
chromosome: Z
Exon count:
21
Annotation release Status Assembly Chr Location
106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) Z NC_052572.1 (39801446..39873047, complement)
106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) Z NC_059536.1 (39801446..39873047, complement)

Chromosome Z - NC_052572.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107052312 Neighboring gene uncharacterized LOC121108588 Neighboring gene uncharacterized LOC121108589 Neighboring gene uncharacterized LOC121108590

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Establishment of motor neuron-V3 interneuron progenitor domain boundary in ventral spinal cord requires Groucho-mediated transcriptional corepression. Todd KJ, et al. PLoS One, 2012. PMID 22363571, Free PMC Article
  2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. TLE is important to promote the formation of the p3 domain and subsequent generation of V3 interneurons.
    Title: Establishment of motor neuron-V3 interneuron progenitor domain boundary in ventral spinal cord requires Groucho-mediated transcriptional corepression.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables transcription corepressor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in negative regulation of canonical Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 PubMed 
part_of transcription regulator complex IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
transducin-like enhancer protein 1
Names
transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

  1. NC_052572.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Range
    39801446..39873047 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_015280363.4 → XP_015135849.1  transducin-like enhancer protein 1 isoform X4

    UniProtKB/TrEMBL
    A0A8V0YT62
    Related
    ENSGALP00010021907.1, ENSGALT00010037973.1
    Conserved Domains (4) summary
    PHA03247
    Location:318 → 475
    PHA03247; large tegument protein UL36; Provisional
    cd00200
    Location:482 → 766
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:486 → 525
    7WD40; WD40 repeat [structural motif]
    pfam03920
    Location:9 → 132
    TLE_N; Groucho/TLE N-terminal Q-rich domain

  2. XM_003643035.6 → XP_003643083.1  transducin-like enhancer protein 1 isoform X3

    UniProtKB/TrEMBL
    A0A8V0YT62
    Related
    ENSGALP00010021904.1, ENSGALT00010037964.1
    Conserved Domains (4) summary
    PHA03247
    Location:319 → 476
    PHA03247; large tegument protein UL36; Provisional
    cd00200
    Location:483 → 767
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:487 → 526
    7WD40; WD40 repeat [structural motif]
    pfam03920
    Location:9 → 133
    TLE_N; Groucho/TLE N-terminal Q-rich domain

  3. XM_015280362.4 → XP_015135848.1  transducin-like enhancer protein 1 isoform X2

    UniProtKB/TrEMBL
    A0A8V0YT62
    Related
    ENSGALP00010021903.1, ENSGALT00010037963.1
    Conserved Domains (4) summary
    COG2319
    Location:485 → 777
    WD40; WD40 repeat [General function prediction only]
    cd00200
    Location:492 → 776
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    pfam03920
    Location:1 → 142
    TLE_N; Groucho/TLE N-terminal Q-rich domain
    sd00039
    Location:496 → 535
    7WD40; WD40 repeat [structural motif]

  4. XM_004949181.5 → XP_004949238.1  transducin-like enhancer protein 1 isoform X1

    UniProtKB/TrEMBL
    A0A1D5P5C3, A0A8V0YT62
    Related
    ENSGALP00010021908.1, ENSGALT00010037976.1
    Conserved Domains (4) summary
    PHA03247
    Location:329 → 486
    PHA03247; large tegument protein UL36; Provisional
    cd00200
    Location:493 → 777
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:497 → 536
    7WD40; WD40 repeat [structural motif]
    pfam03920
    Location:9 → 143
    TLE_N; Groucho/TLE N-terminal Q-rich domain

  5. XM_015280364.3 → XP_015135850.1  transducin-like enhancer protein 1 isoform X5

    UniProtKB/TrEMBL
    A0A1D5PGR2
    Related
    ENSGALP00010021900.1, ENSGALT00010037955.1
    Conserved Domains (4) summary
    COG2319
    Location:411 → 703
    WD40; WD40 repeat [General function prediction only]
    cd00200
    Location:418 → 702
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    pfam03920
    Location:2 → 68
    TLE_N; Groucho/TLE N-terminal Q-rich domain
    sd00039
    Location:422 → 461
    7WD40; WD40 repeat [structural motif]

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

  1. NC_059536.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Range
    39801446..39873047 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_046936734.1 → XP_046792690.1  transducin-like enhancer protein 1 isoform X4

    UniProtKB/TrEMBL
    A0A8V0YT62

  2. XM_046936733.1 → XP_046792689.1  transducin-like enhancer protein 1 isoform X3

    UniProtKB/TrEMBL
    A0A8V0YT62

  3. XM_046936732.1 → XP_046792688.1  transducin-like enhancer protein 1 isoform X2

    UniProtKB/TrEMBL
    A0A8V0YT62

  4. XM_046936731.1 → XP_046792687.1  transducin-like enhancer protein 1 isoform X1

    UniProtKB/TrEMBL
    A0A1D5P5C3, A0A8V0YT62

  5. XM_046936735.1 → XP_046792691.1  transducin-like enhancer protein 1 isoform X5

    UniProtKB/TrEMBL
    A0A1D5PGR2
Nucleotide Protein
Heading Accession and Version

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