bb8 big bubble 8 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: bb8provided by FlyBase
Official Full Name: big bubble 8provided by FlyBase
Primary source: FLYBASE:FBgn0039071
Locus tag: Dmel_CG4434
See related: AllianceGenome:FB:FBgn0039071
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG4434; Dmel\CG4434; FBgn0039071
Summary: Enables glutamate dehydrogenase (NAD+) activity. Involved in glutamate catabolic process and negative regulation of mitochondrial fission. Located in mitochondrion. Is expressed in adult head; elongation stage spermatid; primary spermatocyte; spermatid cyst; and spermatozoon. Human ortholog(s) of this gene implicated in familial hyperinsulinemic hypoglycemia 6; hyperinsulinism; and hypoglycemia. Orthologous to human GLUD1 (glutamate dehydrogenase 1). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (23288217..23290189, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3R	NT_033777.2 (19113939..19115911, complement)

Chromosome 3R - NT_033777.3 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables glutamate dehydrogenase (NAD+) activity	IBA Inferred from Biological aspect of Ancestor more info
enables glutamate dehydrogenase (NAD+) activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in amino acid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in glutamate catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in glutamate catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of mitochondrial fission	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in mitochondrial matrix	ISS Inferred from Sequence or Structural Similarity more info
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	IDA Inferred from Direct Assay more info	PubMed

NP_651140.1

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The following sections contain reference sequences that belong to a specific genome build. Explain