SPE Spatzle-Processing Enzyme [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: SPEprovided by FlyBase
Official Full Name: Spatzle-Processing Enzymeprovided by FlyBase
Primary source: FLYBASE:FBgn0039102
Locus tag: Dmel_CG16705
See related: AllianceGenome:FB:FBgn0039102
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: c-SP4; CG16705; cSP4; CT37173; Dmel\CG16705; proPO-AE; Sp4; SP4; spe
Summary: Enables serine-type endopeptidase activity. Involved in several processes, including Toll receptor ligand protein activation cascade; defense response to other organism; and positive regulation of antimicrobial peptide production. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in adult head; embryonic/larval fat body; and wing disc. [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: all
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Genomic context

Location:: 95A7-95A7; 3-80 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (23686255..23688147)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3R	NT_033777.2 (19511977..19513869)

Chromosome 3R - NT_033777.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

an unidentified protease besides SPE processes Spatzle under conditions of microbial challenge
Title: Spätzle-Processing Enzyme-independent Activation of the Toll Pathway in Drosophila Innate Immunity.

Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables serine hydrolase activity	HDA more info	PubMed
enables serine-type endopeptidase activity	IDA Inferred from Direct Assay more info	PubMed
enables serine-type endopeptidase activity	IEA Inferred from Electronic Annotation more info
enables serine-type endopeptidase activity	ISM Inferred from Sequence Model more info	PubMed

Process	Evidence Code	Pubs
involved_in Toll receptor ligand protein activation cascade	IDA Inferred from Direct Assay more info	PubMed
involved_in Toll receptor ligand protein activation cascade	IGI Inferred from Genetic Interaction more info	PubMed
involved_in Toll receptor ligand protein activation cascade	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in defense response to Gram-negative bacterium	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in defense response to Gram-positive bacterium	IDA Inferred from Direct Assay more info	PubMed
involved_in defense response to Gram-positive bacterium	IGI Inferred from Genetic Interaction more info	PubMed
involved_in defense response to Gram-positive bacterium	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in defense response to fungus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in innate immune response	IBA Inferred from Biological aspect of Ancestor more info
involved_in innate immune response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of antifungal peptide production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of antimicrobial peptide production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of biosynthetic process of antibacterial peptides active against Gram-positive bacteria	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in proteolysis	IDA Inferred from Direct Assay more info	PubMed
involved_in proteolysis	IEA Inferred from Electronic Annotation more info
involved_in proteolysis	ISM Inferred from Sequence Model more info	PubMed
involved_in response to fungus	HEP more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular region	IC Inferred by Curator more info	PubMed
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: Spatzle-Processing enzyme

Names: CG16705-PA; SPE-PA; Spz-processing enzyme; pasteur; spz processing enzyme

NP_651168.1

EC 3.4.21.-

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033777.3 Reference assembly

Range

23686255..23688147

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_142911.4 → NP_651168.1 Spatzle-Processing enzyme [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_651168.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q9VCJ8

Related

FBpp0083832

Conserved Domains (2) summary

cd00190
Location:135 → 397

Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

pfam12032
Location:42 → 94

CLIP; Regulatory CLIP domain of proteinases