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MBTPS2 membrane bound transcription factor peptidase, site 2 [ Gallus gallus (chicken) ]

Gene ID: 427996, updated on 17-Aug-2024

Summary

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Symbol
MBTPS2provided by CGNC
Full Name
membrane bound transcription factor peptidase, site 2provided by CGNC
Primary source
CGNC:12260
See related
Ensembl:ENSGALG00010003275
Gene type
protein coding
RefSeq status
MODEL
Organism
Gallus gallus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Orthologs
human mouse all
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Genomic context

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See MBTPS2 in Genome Data Viewer
Location:
chromosome: 1
Exon count:
13
Annotation release Status Assembly Chr Location
106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 1 NC_052532.1 (119167209..119202090, complement)
106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 1 NC_052573.1 (119200452..119235290, complement)

Chromosome 1 - NC_052532.1Genomic Context describing neighboring genes Neighboring gene phosphate regulating endopeptidase homolog X Neighboring gene spermine synthase Neighboring gene uncharacterized LOC107049256 Neighboring gene uncharacterized LOC121109221 Neighboring gene small muscle protein X Neighboring gene uncharacterized LOC121109220

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables metalloendopeptidase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in membrane protein intracellular domain proteolysis IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of DNA-binding transcription factor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of response to endoplasmic reticulum stress IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
membrane-bound transcription factor site-2 protease
XP_004934718.1
XP_040515510.1
XP_040515511.1
XP_046765349.1
XP_425566.3

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

  1. NC_052532.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Range
    119167209..119202090 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_425566.8 → XP_425566.3  membrane-bound transcription factor site-2 protease isoform X1

    UniProtKB/TrEMBL
    A0A3Q2TYD2
    Related
    ENSGALP00010004620.1, ENSGALT00010007689.1
    Conserved Domains (2) summary
    cd06162
    Location:6 → 217
    S2P-M50_PDZ_SREBP; Sterol regulatory element-binding protein (SREBP) Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50A), regulates intramembrane proteolysis (RIP) of SREBP and is part of a signal transduction mechanism involved in sterol and lipid ...
    pfam02163
    Location:134 → 475
    Peptidase_M50; Peptidase family M50

  2. XM_004934661.5 → XP_004934718.1  membrane-bound transcription factor site-2 protease isoform X2

    UniProtKB/TrEMBL
    E1BR82
    Related
    ENSGALP00010004618.1, ENSGALT00010007687.1
    Conserved Domains (2) summary
    cd06162
    Location:4 → 196
    S2P-M50_PDZ_SREBP; Sterol regulatory element-binding protein (SREBP) Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50A), regulates intramembrane proteolysis (RIP) of SREBP and is part of a signal transduction mechanism involved in sterol and lipid ...
    pfam02163
    Location:113 → 454
    Peptidase_M50; Peptidase family M50

RNA

  1. XR_001461721.4 RNA Sequence

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

  1. NC_052573.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Range
    119200452..119235290 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_040659576.2 → XP_040515510.1  membrane-bound transcription factor site-2 protease isoform X1

    UniProtKB/TrEMBL
    A0A3Q2TYD2
    Conserved Domains (2) summary
    cd06162
    Location:6 → 217
    S2P-M50_PDZ_SREBP; Sterol regulatory element-binding protein (SREBP) Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50A), regulates intramembrane proteolysis (RIP) of SREBP and is part of a signal transduction mechanism involved in sterol and lipid ...
    pfam02163
    Location:134 → 475
    Peptidase_M50; Peptidase family M50

  2. XM_046909393.1 → XP_046765349.1  membrane-bound transcription factor site-2 protease isoform X3

  3. XM_040659577.2 → XP_040515511.1  membrane-bound transcription factor site-2 protease isoform X2

    UniProtKB/TrEMBL
    E1BR82
    Conserved Domains (2) summary
    cd06162
    Location:4 → 196
    S2P-M50_PDZ_SREBP; Sterol regulatory element-binding protein (SREBP) Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50A), regulates intramembrane proteolysis (RIP) of SREBP and is part of a signal transduction mechanism involved in sterol and lipid ...
    pfam02163
    Location:113 → 454
    Peptidase_M50; Peptidase family M50

RNA

  1. XR_005844437.2 RNA Sequence

Nucleotide Protein
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