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Hrd3 HMG-coA reductase degradation 3 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 42806, updated on 9-Dec-2024

Summary

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Official Symbol
Hrd3provided by FlyBase
Official Full Name
HMG-coA reductase degradation 3provided by FlyBase
Primary source
FLYBASE:FBgn0028475
Locus tag
Dmel_CG10221
See related
AllianceGenome:FB:FBgn0028475
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
BcDNA:LD23587; CG10221; Dmel\CG10221; hrd3; HRD3
Summary
Predicted to be involved in ERAD pathway. Predicted to be active in endoplasmic reticulum membrane. Is expressed in adult head and organism. Human ortholog(s) of this gene implicated in pancreatic cancer. Orthologous to several human genes including SEL1L (SEL1L adaptor subunit of SYVN1 ubiquitin ligase). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See Hrd3 in Genome Data Viewer
Location:
95B1-95B1; 3-80 cM
Exon count:
8
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (23754623..23758557, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (19580345..19584279, complement)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene HMG Coenzyme A reductase Neighboring gene Ran binding protein 3 Neighboring gene Regulatory particle triple-A ATPase 5 Neighboring gene Protein tyrosine phosphatase, mitochondrial 1 Neighboring gene Succinate dehydrogenase, subunit D Neighboring gene undicht

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. eIF2α kinases PERK and GCN2 act on FOXO to potentiate FOXO activity. You S, et al. Genes Cells, 2018 Sep. PMID 30043468
  2. Naringenin Ameliorates Drosophila ReepA Hereditary Spastic Paraplegia-Linked Phenotypes. Napoli B, et al. Front Neurosci, 2019. PMID 31803000, Free PMC Article
  3. Suppression of retinal degeneration in Drosophila by stimulation of ER-associated degradation. Kang MJ, et al. Proc Natl Acad Sci U S A, 2009 Oct 6. PMID 19805114, Free PMC Article
  4. Exploring the Conserved Role of MANF in the Unfolded Protein Response in Drosophila melanogaster. Lindström R, et al. PLoS One, 2016. PMID 26975047, Free PMC Article
  5. Wolbachia endosymbionts subvert the endoplasmic reticulum to acquire host membranes without triggering ER stress. Fattouh N, et al. PLoS Negl Trop Dis, 2019 Mar. PMID 30893296, Free PMC Article

See all (40) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by FlyBase

Process Evidence Code Pubs
involved_in ERAD pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
HMG-coA reductase degradation 3
Names
CG10221-PA
CG10221-PB
Hrd3-PA
Hrd3-PB

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    23754623..23758557 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001275953.1 → NP_001262882.1  HMG-coA reductase degradation 3, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001262882.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9V415
    Conserved Domains (3) summary
    smart00671
    Location:407 → 441
    SEL1; Sel1-like repeats
    COG0790
    Location:334 → 649
    TPR; TPR repeat [Signal transduction mechanisms]
    sd00010
    Location:353 → 382
    SLR; SLR repeat [structural motif]

  2. NM_142922.3 → NP_651179.1  HMG-coA reductase degradation 3, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_651179.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9V415
    Related
    FBpp0083858
    Conserved Domains (3) summary
    smart00671
    Location:407 → 441
    SEL1; Sel1-like repeats
    COG0790
    Location:334 → 649
    TPR; TPR repeat [Signal transduction mechanisms]
    sd00010
    Location:353 → 382
    SLR; SLR repeat [structural motif]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9V415 Q9V415

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