U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

PTPMT1 Protein tyrosine phosphatase, mitochondrial 1 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 42807, updated on 4-Jan-2025

Summary

Go to the top of the page Help
Official Symbol
PTPMT1provided by FlyBase
Official Full Name
Protein tyrosine phosphatase, mitochondrial 1provided by FlyBase
Primary source
FLYBASE:FBgn0039111
Locus tag
Dmel_CG10371
See related
AllianceGenome:FB:FBgn0039111
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
150466_at; CG10371; Dmel\CG10371; dPTEN; dPTPMT1; plip; Plip; PLIP
Summary
Predicted to enable phosphatidylglycerophosphatase activity and phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity. Predicted to be involved in cardiolipin biosynthetic process. Is active in mitochondrion. Is expressed in several structures, including adult head; embryonic dorsal epidermis; embryonic head epidermis; embryonic ventral epidermis; and gut section. Orthologous to human PTPMT1 (protein tyrosine phosphatase mitochondrial 1). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See PTPMT1 in Genome Data Viewer
Location:
95B1-95B1; 3-80 cM
Exon count:
4
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (23758339..23759606)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (19584061..19585328)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene HMG Coenzyme A reductase Neighboring gene Ran binding protein 3 Neighboring gene Regulatory particle triple-A ATPase 5 Neighboring gene HMG-coA reductase degradation 3 Neighboring gene Succinate dehydrogenase, subunit D Neighboring gene undicht Neighboring gene Lipid storage droplet-1 Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. A PTEN-like phosphatase with a novel substrate specificity. Pagliarini DJ, et al. J Biol Chem, 2004 Sep 10. PMID 15247229
  2. Drosophila PTPMT1 Has a Function in Tracheal Air Filling. Papakyrikos AM, et al. iScience, 2020 Jul 24. PMID 32629421, Free PMC Article
  3. Pathogenic VCP/TER94 alleles are dominant actives and contribute to neurodegeneration by altering cellular ATP level in a Drosophila IBMPFD model. Chang YC, et al. PLoS Genet, 2011 Feb 3. PMID 21304887, Free PMC Article
  4. A conserved myotubularin-related phosphatase regulates autophagy by maintaining autophagic flux. Allen EA, et al. J Cell Biol, 2020 Nov 2. PMID 32915229, Free PMC Article
  5. A Drosophila-centric view of protein tyrosine phosphatases. Hatzihristidis T, et al. FEBS Lett, 2015 Apr 13. PMID 25771859

See all (33) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables phosphatidylglycerophosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables phosphoprotein phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cardiolipin biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in protein dephosphorylation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in mitochondrial inner membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in mitochondrion IMP
Inferred from Mutant Phenotype
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
protein tyrosine phosphatase, mitochondrial 1
Names
CG10371-PA
CG10371-PB
MKP-like
PTEN-like phosphatase
PTPMT1-PA
PTPMT1-PB
NP_651180.3
NP_732901.1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    23758339..23759606
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_142923.3 → NP_651180.3  protein tyrosine phosphatase, mitochondrial 1, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_651180.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q86BN8, Q8SZ90, Q9VCI6
    UniProtKB/TrEMBL
    B5RJ36
    Related
    FBpp0083844
    Conserved Domains (1) summary
    cd14524
    Location:31 → 194
    PTPMT1; protein-tyrosine phosphatase mitochondrial 1

  2. NM_170090.2 → NP_732901.1  protein tyrosine phosphatase, mitochondrial 1, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_732901.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q86BN8
    Related
    FBpp0083845
    Conserved Domains (1) summary
    cl21483
    Location:55 → 186
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q86BN8.1 Q86BN8

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Other Literature Sources
Chemical Information
Molecular Biology Databases
Research Materials
Tools