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NTF3 neurotrophin 3 [ Gallus gallus (chicken) ]

Gene ID: 428099, updated on 3-Dec-2024

Summary

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Symbol
NTF3provided by CGNC
Full Name
neurotrophin 3provided by CGNC
Primary source
CGNC:53263
See related
Ensembl:ENSGALG00010024492
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Gallus gallus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Also known as
NT3; HDNF; NGF2; NT-3; NGF-2; neurotrophin-3
Orthologs
human mouse all
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Genomic context

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See NTF3 in Genome Data Viewer
Location:
chromosome: 1
Exon count:
3
Annotation release Status Assembly Chr Location
106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 1 NC_052532.1 (74314666..74387752)
106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 1 NC_052573.1 (74643530..74716695)

Chromosome 1 - NC_052532.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107054307 Neighboring gene potassium voltage-gated channel subfamily A member 5 Neighboring gene anoctamin 2 Neighboring gene uncharacterized LOC124417639 Neighboring gene von Willebrand factor

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Neurotrophic factor NT-3 displays a non-canonical cell guidance signaling function for cephalic neural crest cells. Zanin JP, et al. Eur J Cell Biol, 2013 Aug-Sep. PMID 24252516
  2. Cellular localization of brain-derived neurotrophic factor and neurotrophin-3 mRNA expression in the early chicken embryo. Hallböök F, et al. Eur J Neurosci, 1993 Jan 1. PMID 8074744
  3. Neurotrophin-3 and TrkC are expressed in the outflow tract of the developing chicken heart. Bernd P, et al. Dev Dyn, 2004 Aug. PMID 15254910
  4. Gene sequences of chicken BDNF and NT-3. Maisonpierre PC, et al. DNA Seq, 1992. PMID 1457809
  5. [The expression level of NGF, BDNF and NT-3 in spinal cord of growing embryonic chicken]. Dai P, et al. Sichuan Da Xue Xue Bao Yi Xue Ban, 2009 Jul. PMID 19764571

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The chemotactic response of NCCs toward the ocular region NT-3 gradient is essential for spatiotemporal cell orientation, amplifying the functional scope of this neurotrophic factor as a molecular guide for the embryo cells.
    Title: Neurotrophic factor NT-3 displays a non-canonical cell guidance signaling function for cephalic neural crest cells.
  2. Levels of NGF, BDNF and NT-3 were all up regulated from E7 to E14 in the spinal cord of embryonic chicken during development.
    Title: [The expression level of NGF, BDNF and NT-3 in spinal cord of growing embryonic chicken].
  3. Neurotrophin-3 and TrkC are expressed in the outflow tract of the developing chicken heart
    Title: Neurotrophin-3 and TrkC are expressed in the outflow tract of the developing chicken heart.
Submit: New GeneRIF Correction

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables growth factor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables nerve growth factor receptor binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell surface receptor protein tyrosine kinase signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in memory IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in negative regulation of neuron apoptotic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in nerve development IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in nerve growth factor signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in neuron projection morphogenesis IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of peptidyl-serine phosphorylation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of neuron differentiation IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
neurotrophin-3
Names
nerve growth factor 2
neurotrophic factor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001031488.2 → NP_001026659.1  neurotrophin-3 isoform 2 preproprotein

    See identical proteins and their annotated locations for NP_001026659.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1, and is also intronless. The encoded protein (isoform 2) is shorter and has a distinct N-terminus, compared to isoform 1.
    Source sequence(s)
    JAENSK010000012
    UniProtKB/Swiss-Prot
    P25433, Q6LAC6
    UniProtKB/TrEMBL
    B4ZEM2
    Conserved Domains (1) summary
    pfam00243
    Location:144 → 255
    NGF; Nerve growth factor family

  2. NM_001109762.2 → NP_001103232.1  neurotrophin-3 isoform 1 preproprotein

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer protein (isoform 1).
    Source sequence(s)
    JAENSK010000012
    UniProtKB/TrEMBL
    A0A3Q2U804, A0A8V0ZSN3
    Related
    ENSGALP00010036511.1, ENSGALT00010059751.1
    Conserved Domains (1) summary
    pfam00243
    Location:157 → 266
    NGF; Nerve growth factor family

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

  1. NC_052532.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Range
    74314666..74387752
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_040701581.2 → XP_040557515.1  neurotrophin-3 isoform X1

    UniProtKB/Swiss-Prot
    P25433, Q6LAC6
    UniProtKB/TrEMBL
    B4ZEM2
    Related
    ENSGALP00010036497.1, ENSGALT00010059737.1
    Conserved Domains (1) summary
    pfam00243
    Location:144 → 255
    NGF; Nerve growth factor family

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

  1. NC_052573.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Range
    74643530..74716695
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_046908592.1 → XP_046764548.1  neurotrophin-3 isoform X1

    UniProtKB/Swiss-Prot
    P25433, Q6LAC6
    UniProtKB/TrEMBL
    B4ZEM2
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P25433.2 GenPept UniProtKB/Swiss-Prot:P25433

Gene LinkOut

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