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tbrd-1 testis-specifically expressed bromodomain containing protein-1 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 42823, updated on 9-Dec-2024

Summary

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Official Symbol
tbrd-1provided by FlyBase
Official Full Name
testis-specifically expressed bromodomain containing protein-1provided by FlyBase
Primary source
FLYBASE:FBgn0039124
Locus tag
Dmel_CG13597
See related
AllianceGenome:FB:FBgn0039124
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG13597; Dmel\CG13597; tBrd-1; tBRD-1
Summary
Enables chromatin binding activity. Involved in spermatid differentiation. Located in chromosome; nuclear body; and nucleolus. Part of precatalytic spliceosome. Is expressed in primary spermatocyte; spermatocyte; and testis. Human ortholog(s) of this gene implicated in juvenile myoclonic epilepsy; lymphoma (multiple); male infertility (multiple); and photosensitivity disease. Orthologous to human BRD2 (bromodomain containing 2); BRD3 (bromodomain containing 3); and BRDT (bromodomain testis associated). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See tbrd-1 in Genome Data Viewer
Location:
95C8-95C9; 3-81 cM
Exon count:
2
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (23891597..23893560, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (19717319..19719105, complement)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Pellino Neighboring gene Transcription-factor-IIA-S Neighboring gene pseudo Neighboring gene six-banded Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Two bromodomain proteins functionally interact to recapitulate an essential BRDT-like function in Drosophila spermatocytes. Kimura S, et al. Open Biol, 2015 Feb. PMID 25652540, Free PMC Article
  2. Nejire/dCBP-mediated histone H3 acetylation during spermatogenesis is essential for male fertility in Drosophila melanogaster. Hundertmark T, et al. PLoS One, 2018. PMID 30192860, Free PMC Article
  3. The bromodomain-containing protein tBRD-1 is specifically expressed in spermatocytes and is essential for male fertility. Leser K, et al. Biol Open, 2012 Jun 15. PMID 23213453, Free PMC Article
  4. Drosophila melanogaster tPlus3a and tPlus3b ensure full male fertility by regulating transcription of Y-chromosomal, seminal fluid, and heat shock genes. Hundertmark T, et al. PLoS One, 2019. PMID 30845228, Free PMC Article
  5. A Drosophila toolkit for defining gene function in spermatogenesis. Siddall NA, et al. Reproduction, 2017 Apr. PMID 28073824

See all (37) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. These data confirmed that tBRD-1 controls gene activity in male germ cells.
    Title: tBRD-1 selectively controls gene activity in the Drosophila testis and interacts with two new members of the bromodomain and extra-terminal (BET) family.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables chromatin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables chromatin binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables histone binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in chromatin remodeling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mRNA splicing, via spliceosome IC
Inferred by Curator
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in spermatid differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in spermatogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in chromatin IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in chromosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nuclear body IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleolus IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of precatalytic spliceosome HDA PubMed 

General protein information

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Preferred Names
testis-specifically expressed bromodomain containing protein-1
Names
CG13597-PA
CG13597-PB
tbrd-1-PA
tbrd-1-PB

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    23891597..23893560 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001382023.1 → NP_001369030.1  testis-specifically expressed bromodomain containing protein-1, isoform B [Drosophila melanogaster]

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q058W2, Q9VCG6
    Conserved Domains (1) summary
    cl02556
    Location:39 → 143
    Bromodomain; Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine.

  2. NM_142933.2 → NP_651190.1  testis-specifically expressed bromodomain containing protein-1, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_651190.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q058W2, Q9VCG6
    Related
    FBpp0083911
    Conserved Domains (1) summary
    cl02556
    Location:39 → 143
    Bromodomain; Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VCG6 Q9VCG6

Gene LinkOut

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