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sba six-banded [ Drosophila melanogaster (fruit fly) ]

Gene ID: 42824, updated on 9-Dec-2024

Summary

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Official Symbol
sbaprovided by FlyBase
Official Full Name
six-bandedprovided by FlyBase
Primary source
FLYBASE:FBgn0016754
Locus tag
Dmel_CG13598
See related
AllianceGenome:FB:FBgn0016754
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
AAF56201; CG13598; Dm Sba; dMBD5/6; Dmel\CG13598; DMTF125; F125; MBD5; SBA; Tf125; TF125
Summary
Predicted to enable chromatin binding activity. Predicted to be active in chromocenter and nucleus. Human ortholog(s) of this gene implicated in autism spectrum disorder and autosomal dominant intellectual developmental disorder 1. Orthologous to several human genes including MBD5 (methyl-CpG binding domain protein 5). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
all
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Genomic context

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See sba in Genome Data Viewer
Location:
95C9-95C12; 3-81 cM
Exon count:
10
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (23894174..23922973, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (19719896..19748695, complement)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Transcription-factor-IIA-S Neighboring gene testis-specifically expressed bromodomain containing protein-1 Neighboring gene pseudo Neighboring gene uncharacterized protein Neighboring gene Nuclear division cycle 1 Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. six-banded, a novel Drosophila gene, is expressed in 6 segmental stripes during embryonic development and in the eye imaginal disc. Zeidler MP, et al. Biol Chem, 1997 Oct. PMID 9372180
  2. Gene dosage and selective expression modify phenotype in a Drosophila model of human mitochondrial disease. Toivonen JM, et al. Mitochondrion, 2003 Oct. PMID 16120347
  3. Population genetic evidence for cold adaptation in European Drosophila melanogaster populations. Božičević V, et al. Mol Ecol, 2016 Mar. PMID 26558479
  4. Disruption of an EHMT1-associated chromatin-modification module causes intellectual disability. Kleefstra T, et al. Am J Hum Genet, 2012 Jul 13. PMID 22726846, Free PMC Article
  5. Patterns of diversity and linkage disequilibrium within the cosmopolitan inversion In(3R)Payne in Drosophila melanogaster are indicative of coadaptation. Kennington WJ, et al. Genetics, 2006 Mar. PMID 16322502, Free PMC Article

See all (45) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables chromatin binding ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
Component Evidence Code Pubs
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
six-banded
Names
CG13598-PC
CG13598-PD
CG13598-PE
CG13598-PF
CG13598-PG
CG13598-PH
CG13598-PI
TF125 type II
methyl-CpG-binding domain protein 5/6
sba-PC
sba-PD
sba-PE
sba-PF
sba-PG
sba-PH
sba-PI

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    23894174..23922973 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_176549.3 → NP_788726.2  six-banded, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_788726.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A0A0B4K7E4, A0A0B4KHQ9, A0A0B4KHZ2, A0A0C4DHB2, A8JR92, A8JR93, Q24552, Q94892
    UniProtKB/TrEMBL
    Q95TH4
    Conserved Domains (2) summary
    smart00391
    Location:241 → 315
    MBD; Methyl-CpG binding domain
    cl02554
    Location:1344 → 1440
    PWWP; The PWWP domain, named for a conserved Pro-Trp-Trp-Pro motif, is a small domain consisting of 100-150 amino acids. The PWWP domain is found in numerous proteins that are involved in cell division, growth and differentiation. Most PWWP-domain proteins ...

  2. NM_170094.4 → NP_732911.2  six-banded, isoform G [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_732911.2

    Status: REVIEWED

    Conserved Domains (1) summary
    smart00391
    Location:241 → 315
    MBD; Methyl-CpG binding domain

  3. NM_001260342.2 → NP_001247271.1  six-banded, isoform F [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001247271.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q95TH4
    Conserved Domains (1) summary
    smart00391
    Location:241 → 315
    MBD; Methyl-CpG binding domain

  4. NM_001104423.2 → NP_001097893.1  six-banded, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001097893.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A0A0B4K7E4, A0A0B4KHQ9, A0A0B4KHZ2, A0A0C4DHB2, A8JR92, A8JR93, Q24552, Q94892
    UniProtKB/TrEMBL
    Q95TH4
    Conserved Domains (2) summary
    smart00391
    Location:241 → 315
    MBD; Methyl-CpG binding domain
    cl02554
    Location:1344 → 1440
    PWWP; The PWWP domain, named for a conserved Pro-Trp-Trp-Pro motif, is a small domain consisting of 100-150 amino acids. The PWWP domain is found in numerous proteins that are involved in cell division, growth and differentiation. Most PWWP-domain proteins ...

  5. NM_001275959.1 → NP_001262888.1  six-banded, isoform H [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001262888.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q95TH4
    Conserved Domains (2) summary
    smart00391
    Location:241 → 315
    MBD; Methyl-CpG binding domain
    cl02554
    Location:1344 → 1440
    PWWP; The PWWP domain, named for a conserved Pro-Trp-Trp-Pro motif, is a small domain consisting of 100-150 amino acids. The PWWP domain is found in numerous proteins that are involved in cell division, growth and differentiation. Most PWWP-domain proteins ...

  6. NM_001275960.1 → NP_001262889.1  six-banded, isoform I [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001262889.1

    Status: REVIEWED

    Conserved Domains (1) summary
    smart00391
    Location:241 → 315
    MBD; Methyl-CpG binding domain

  7. NM_001104422.3 → NP_001097892.1  six-banded, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001097892.1

    Status: REVIEWED

    Conserved Domains (1) summary
    smart00391
    Location:241 → 315
    MBD; Methyl-CpG binding domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A0B4K7E4 A0A0B4K7E4
A0A0B4KHQ9 A0A0B4KHQ9
A0A0B4KHZ2 A0A0B4KHZ2
A0A0C4DHB2 A0A0C4DHB2
A8JR92 A8JR92
A8JR93 A8JR93
Q24552 Q24552
Q94892 Q94892
Q95TH4 Q95TH4

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