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CG43999 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

Gene ID: 42827, updated on 9-Dec-2024

Summary

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Official Symbol
CG43999provided by FlyBase
Official Full Name
uncharacterized proteinprovided by FlyBase
Primary source
FLYBASE:FBgn0264741
Locus tag
Dmel_CG43999
See related
AllianceGenome:FB:FBgn0264741
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
BcDNA:AT03227; CG13602; CR43999; Dmel\CG43999
Summary
Predicted to be involved in regulation of lipid metabolic process. Predicted to be active in mitochondrion. Human ortholog(s) of this gene implicated in 3-methylglutaconic aciduria type 3 and optic atrophy 3. Orthologous to human OPA3 (outer mitochondrial membrane lipid metabolism regulator OPA3). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
all
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Genomic context

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See CG43999 in Genome Data Viewer
Location:
95C13-95C13; 3-81 cM
Exon count:
4
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (23927728..23929000, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (19753450..19754722, complement)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Nuclear division cycle 1 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Regulatory particle triple-A ATPase 2 Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A genome-wide analysis of courting and mating responses in Drosophila melanogaster females. Lawniczak MK, et al. Genome, 2004 Oct. PMID 15499404
  2. Drosophila p53 directs nonapoptotic programs in postmitotic tissue. Kurtz P, et al. Mol Biol Cell, 2019 May 15. PMID 30892991, Free PMC Article
  3. Identification of genes that promote or inhibit olfactory memory formation in Drosophila. Walkinshaw E, et al. Genetics, 2015 Apr. PMID 25644700, Free PMC Article
  4. Transcriptomic analysis of inbreeding depression in cold-sensitive Drosophila melanogaster shows upregulation of the immune response. Vermeulen CJ, et al. J Evol Biol, 2013 Sep. PMID 23944235
  5. The genetic basis for variation in olfactory behavior in Drosophila melanogaster. Arya GH, et al. Chem Senses, 2015 May. PMID 25687947, Free PMC Article

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in regulation of lipid metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
uncharacterized protein
Names
CG43999-PB
CG43999-PC

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    23927728..23929000 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001300561.1 → NP_001287490.1  uncharacterized protein Dmel_CG43999, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001287490.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q0KI22
    Conserved Domains (1) summary
    pfam07047
    Location:9 → 127
    OPA3; Optic atrophy 3 protein (OPA3)

  2. NM_001043284.2 → NP_001036749.2  uncharacterized protein Dmel_CG43999, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001036749.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q0KI22
    Conserved Domains (1) summary
    pfam07047
    Location:9 → 127
    OPA3; Optic atrophy 3 protein (OPA3)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q0KI22 Q0KI22

Gene LinkOut

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