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Rpt2 Regulatory particle triple-A ATPase 2 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 42828, updated on 9-Dec-2024

Summary

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Official Symbol
Rpt2provided by FlyBase
Official Full Name
Regulatory particle triple-A ATPase 2provided by FlyBase
Primary source
FLYBASE:FBgn0015282
Locus tag
Dmel_CG5289
See related
AllianceGenome:FB:FBgn0015282
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
5289; CG5289; Dm-S4-1; Dmel\CG5289; DmP26S4; Dm_Rpt2; dRpt2; P26s4; p56; pros26.4; Pros26.4; PSMC1; rpt2; S4
Summary
Predicted to enable proteasome-activating activity. Involved in proteasome-mediated ubiquitin-dependent protein catabolic process. Part of proteasome regulatory particle, base subcomplex. Is expressed in several structures, including adult head; amnioserosa; ganglia; germline cell; and imaginal disc. Used to study Parkinson's disease; neurodegenerative disease; and neurodevelopmental disorder with poor growth, spastic tetraplegia, and hearing loss. Human ortholog(s) of this gene implicated in neurodevelopmental disorder with poor growth, spastic tetraplegia, and hearing loss. Orthologous to human PSMC1 (proteasome 26S subunit, ATPase 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See Rpt2 in Genome Data Viewer
Location:
95C13-95C13; 3-81 cM
Exon count:
2
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (23929873..23931558, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (19755595..19757280, complement)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Nuclear division cycle 1 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Ribosomal protein S19b

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Dissection of the regulator complex of the Drosophila 26S protease by limited proteolysis. Haracska L, et al. Biochem Biophys Res Commun, 1996 Mar 7. PMID 8602838
  2. PSMC1 variant causes a novel neurological syndrome. Aharoni S, et al. Clin Genet, 2022 Oct. PMID 35861243, Free PMC Article
  3. Mutation of potential MAPK phosphorylation sites in the Notch antagonist Hairless. Nagel AC, et al. Hereditas, 2014 Oct. PMID 25363277
  4. Genomic organization and mapping of the mouse P26s4 ATPase gene: a member of the remarkably conserved AAA gene family. Hoyle J, et al. Genomics, 1996 Jan 1. PMID 8808288
  5. VCP promotes tTAF-target gene expression and spermatocyte differentiation by downregulating mono-ubiquitylated H2A. Butsch TJ, et al. Development, 2023 Jul 15. PMID 37401420, Free PMC Article

See all (96) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. lethal phenotype of Dsk2 overexpression could be rescued in a double transgenic line coexpressing Flag-Dsk2 and Flag-p54. Although the double transgenic line was viable and fertile, it did not restore the proteolytic defects.
    Title: Overexpression of Dsk2/dUbqln results in severe developmental defects and lethality in Drosophila melanogaster that can be rescued by overexpression of the p54/Rpn10/S5a proteasomal subunit.
  2. Data show that Pros26.4 negatively regulates Hairless at the genetic and molecular level, providing a novel mechanism of positive regulation of Notch signalling.
    Title: A molecular link A molecular link between Hairless and Pros26.4, a member of the AAA-ATPase subunits of the proteasome 19S regulatory particle in Drosophila.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
  
enables proteasome-activating activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables proteasome-activating activity ISM
Inferred from Sequence Model
more info
 PubMed 
Process Evidence Code Pubs
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IC
Inferred by Curator
more info
 PubMed 
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of proteasome regulatory particle IDA
Inferred from Direct Assay
more info
 PubMed 
part_of proteasome regulatory particle ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
part_of proteasome regulatory particle, base subcomplex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of proteasome regulatory particle, base subcomplex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of proteasome regulatory particle, base subcomplex ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 

General protein information

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Preferred Names
regulatory particle triple-A ATPase 2
Names
26S proteasome subunit 4 ATPase
CG5289-PA
CG5289-PB
Rpt2-PA
Rpt2-PB
proteasome 26S
proteasome 26S subunit 4 ATPase
proteasome 26S subunit subunit 4 ATPase
NP_001287493.1
NP_524469.2

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    23929873..23931558 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001300564.1 → NP_001287493.1  regulatory particle triple-A ATPase 2, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001287493.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P48601, Q9VCG1
    UniProtKB/TrEMBL
    A0A0B4LIJ0
    Conserved Domains (1) summary
    PTZ00361
    Location:1 → 439
    PTZ00361; 26 proteosome regulatory subunit 4-like protein; Provisional

  2. NM_079745.4 → NP_524469.2  regulatory particle triple-A ATPase 2, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_524469.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P48601, Q9VCG1
    UniProtKB/TrEMBL
    A0A0B4LIJ0
    Related
    FBpp0083906
    Conserved Domains (1) summary
    PTZ00361
    Location:1 → 439
    PTZ00361; 26 proteosome regulatory subunit 4-like protein; Provisional
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A0B4LIJ0 A0A0B4LIJ0
P48601.2 P48601

Gene LinkOut

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