U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

CG6178 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

Gene ID: 42867, updated on 9-Dec-2024

Summary

Go to the top of the page Help
Official Symbol
CG6178provided by FlyBase
Official Full Name
uncharacterized proteinprovided by FlyBase
Primary source
FLYBASE:FBgn0039156
Locus tag
Dmel_CG6178
See related
AllianceGenome:FB:FBgn0039156
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
Dmel\CG6178; FACL
Summary
Enables long-chain fatty acid-CoA ligase activity. Involved in fatty-acyl-CoA biosynthetic process and long-chain fatty acid metabolic process. Predicted to be located in peroxisome. Is expressed in several structures, including adult head; adult heart; epithelium; ganglia; and gut section. [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See CG6178 in Genome Data Viewer
Location:
95E5-95E6; 3-83 cM
Exon count:
3
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (24152347..24154896)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (19978069..19980618)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene p38c MAP kinase Neighboring gene p38a MAP kinase Neighboring gene Myosin 95E Neighboring gene TBC1 domain family member 7 Neighboring gene mitochondrial ribosomal protein S24 Neighboring gene Adenomatous polyposis coli 2 Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Functional conversion of fatty acyl-CoA synthetase to firefly luciferase by site-directed mutagenesis: a key substitution responsible for luminescence activity. Oba Y, et al. FEBS Lett, 2009 Jun 18. PMID 19450587
  2. Luciferase Activity of Insect Fatty Acyl-CoA Synthetases with Synthetic Luciferins. Mofford DM, et al. ACS Chem Biol, 2017 Dec 15. PMID 29073357, Free PMC Article
  3. Catalytic properties of domain-exchanged chimeric proteins between firefly luciferase and Drosophila fatty Acyl-CoA synthetase CG6178. Oba Y, et al. Biosci Biotechnol Biochem, 2006 Nov. PMID 17090919
  4. Latent luciferase activity in the fruit fly revealed by a synthetic luciferin. Mofford DM, et al. Proc Natl Acad Sci U S A, 2014 Mar 25. PMID 24616520, Free PMC Article
  5. Firefly luciferase: an adenylate-forming enzyme for multicatalytic functions. Inouye S. Cell Mol Life Sci, 2010 Feb. PMID 19859663, Free PMC Article

See all (42) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Phylogenetic analysis indicated that firefly luciferase and CG6178 genes belong to the group of plant 4-coumarate
    Title: Enzymatic and genetic characterization of firefly luciferase and Drosophila CG6178 as a fatty acyl-CoA synthetase.
  2. The enzymatic properties of CG6178 including substrate specificity, pH dependency and optimal temperature were close to those of firefly luciferase and rat fatty acyl-CoA synthetase.
    Title: Characterization of CG6178 gene product with high sequence similarity to firefly luciferase in Drosophila melanogaster.
Submit: New GeneRIF Correction

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables CoA-ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables long-chain fatty acid-CoA ligase activity IDA
Inferred from Direct Assay
more info
 PubMed 
NOT enables luciferin monooxygenase activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in acyl-CoA metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in fatty-acyl-CoA biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in long-chain fatty acid metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in peroxisome ISM
Inferred from Sequence Model
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
uncharacterized protein
Names
CG6178-PA
fatty Acyl-CoA synthetase
fatty acyl-CoA synthase
NP_651221.1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    24152347..24154896
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_142964.3 → NP_651221.1  uncharacterized protein Dmel_CG6178 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_651221.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VCC6
    Related
    FBpp0083935
    Conserved Domains (2) summary
    cd05911
    Location:43 → 529
    Firefly_Luc_like; Firefly luciferase of light emitting insects and 4-Coumarate-CoA Ligase (4CL)
    PLN02246
    Location:26 → 537
    PLN02246; 4-coumarate--CoA ligase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VCC6 Q9VCC6

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Other Literature Sources
Molecular Biology Databases
Research Materials
Tools