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Apc2 - Adenomatous polyposis coli 2

Enables beta-catenin binding activity and molecular adaptor activity. Involved in several processes, including embryonic development via the syncytial blastoderm; oogenesis; and regionalization. Located in several cellular components, including apical cortex; basal cortex; and cleavage furrow. Part of beta-catenin destruction complex. Is active in cytosol. Colocalizes with actin filament. Is expressed in several structures, including epithelial cell; ganglia; germ layer; germline stem cell; and imaginal disc. Human ortholog(s) of this gene implicated in several diseases, including Sotos syndrome 3; autosomal recessive intellectual developmental disorder 74; carcinoma (multiple); gastrointestinal system cancer (multiple); and reproductive organ cancer (multiple). Orthologous to human APC (APC regulator of WNT signaling pathway) and APC2 (APC regulator of WNT signaling pathway 2). [provided by Alliance of Genome Resources, Nov 2024]

Genes similar to Apc2

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Species Gene Architecture aa