SMC6 Structural maintenance of chromosomes 6 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: SMC6provided by FlyBase
Official Full Name: Structural maintenance of chromosomes 6provided by FlyBase
Primary source: FLYBASE:FBgn0266282
Locus tag: Dmel_CG5524
See related: AllianceGenome:FB:FBgn0266282
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: AAF56254; CG5524; Dmel\CG5524; Huc-95DE; huc95E; huc[95D-E]; huc[95DE]; huc[95E]; jnj; smc6; Smc6
Summary: Predicted to enable damaged DNA binding activity and single-stranded DNA binding activity. Involved in DNA damage response and response to caffeine. Located in germinal vesicle. Is expressed in spermatozoon. Orthologous to human SMC6 (structural maintenance of chromosomes 6). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (24189050..24193423, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3R	NT_033777.2 (20014772..20019145, complement)

Chromosome 3R - NT_033777.3 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables ATP hydrolysis activity	NAS Non-traceable Author Statement more info	PubMed
enables damaged DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables damaged DNA binding	ISS Inferred from Sequence or Structural Similarity more info
enables single-stranded DNA binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in DNA damage response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in DNA repair	ISS Inferred from Sequence or Structural Similarity more info
involved_in double-strand break repair via homologous recombination	IBA Inferred from Biological aspect of Ancestor more info
involved_in response to caffeine	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of Smc5-Smc6 complex	IBA Inferred from Biological aspect of Ancestor more info
part_of Smc5-Smc6 complex	ISS Inferred from Sequence or Structural Similarity more info	PubMed
located_in germinal vesicle	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info
is_active_in site of double-strand break	IBA Inferred from Biological aspect of Ancestor more info

Names: CG5524-PA; HU- and caffeine-dependent 95D-E; HU- or caffeine-sensitive 95E; SMC6-PA; hydroxyurea- and (or) caffeine-sensitive 95E; java no jive

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The following sections contain reference sequences that belong to a specific genome build. Explain