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Spps Sp1-like factor for pairing sensitive-silencing [ Drosophila melanogaster (fruit fly) ]

Gene ID: 42882, updated on 9-Dec-2024

Summary

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Official Symbol
Sppsprovided by FlyBase
Official Full Name
Sp1-like factor for pairing sensitive-silencingprovided by FlyBase
Primary source
FLYBASE:FBgn0039169
Locus tag
Dmel_CG5669
See related
AllianceGenome:FB:FBgn0039169
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG5669; Dmel\CG5669
Summary
Enables sequence-specific DNA binding activity. Involved in heterochromatin formation. Located in nucleus and polytene chromosome band. Is expressed in organism. Human ortholog(s) of this gene implicated in congenital heart disease and dilated cardiomyopathy. Orthologous to human SP1 (Sp1 transcription factor); SP3 (Sp3 transcription factor); and SP4 (Sp4 transcription factor). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See Spps in Genome Data Viewer
Location:
95F2-95F3; 3-84 cM
Exon count:
1
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (24223445..24226934, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (20049167..20052656, complement)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene twin Neighboring gene uncharacterized protein Neighboring gene caravaggio Neighboring gene Spase 22/23-subunit Neighboring gene uncharacterized protein Neighboring gene Accessory gland protein 95EF

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Global changes of H3K27me3 domains and Polycomb group protein distribution in the absence of recruiters Spps or Pho. Brown JL, et al. Proc Natl Acad Sci U S A, 2018 Feb 20. PMID 29432187, Free PMC Article
  2. The Goddard and Saturn Genes Are Essential for Drosophila Male Fertility and May Have Arisen De Novo. Gubala AM, et al. Mol Biol Evol, 2017 May 1. PMID 28104747, Free PMC Article
  3. Spps, a Drosophila Sp1/KLF family member, binds to PREs and is required for PRE activity late in development. Brown JL, et al. Development, 2010 Aug 1. PMID 20627963, Free PMC Article
  4. A clustered set of three Sp-family genes is ancestral in the Metazoa: evidence from sequence analysis, protein domain structure, developmental expression patterns and chromosomal location. Schaeper ND, et al. BMC Evol Biol, 2010 Mar 30. PMID 20353601, Free PMC Article
  5. Context-dependent role of Pho binding sites in Polycomb complex recruitment in Drosophila. Brown JL, et al. Genetics, 2023 Aug 9. PMID 37216193, Free PMC Article

See all (52) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Spps, a Drosophila Sp1/KLF family member, binds to PREs and is required for PRE activity late in development
    Title: Spps, a Drosophila Sp1/KLF family member, binds to PREs and is required for PRE activity late in development.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in heterochromatin formation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in nucleus HDA PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in polytene chromosome band IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
Sp1-like factor for pairing sensitive-silencing
Names
CG5669-PA
CG5669-PB
Sp1-like factor for pairing Sensitive-silencing
Spps-PA
Spps-PB

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    24223445..24226934 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_142975.3 → NP_651232.1  Sp1-like factor for pairing sensitive-silencing, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_651232.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q2XXX8, Q9VCB2
    Related
    FBpp0083950
    Conserved Domains (5) summary
    COG5651
    Location:33 → 266
    COG5651; PPE-repeat protein [Function unknown]
    sd00017
    Location:742 → 764
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:800 → 822
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:786 → 809
    zf-H2C2_2; Zinc-finger double domain
    cl41773
    Location:281 → 371
    SP1-4_N; N-terminal domain of transcription factor Specificity Proteins (SP) 1-4

  2. NM_001275973.1 → NP_001262902.1  Sp1-like factor for pairing sensitive-silencing, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001262902.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4KHC8, Q2XXX8
    Conserved Domains (4) summary
    COG5048
    Location:725 → 827
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:742 → 764
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:800 → 822
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:786 → 809
    zf-H2C2_2; Zinc-finger double domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A0B4KHC8 A0A0B4KHC8
Q2XXX8 Q2XXX8
Q9VCB2 Q9VCB2

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