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Spase22-23 Spase 22/23-subunit [ Drosophila melanogaster (fruit fly) ]

Gene ID: 42885, updated on 9-Dec-2024

Summary

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Official Symbol
Spase22-23provided by FlyBase
Official Full Name
Spase 22/23-subunitprovided by FlyBase
Primary source
FLYBASE:FBgn0039172
Locus tag
Dmel_CG5677
See related
AllianceGenome:FB:FBgn0039172
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG5677; Dmel\CG5677; Spase22/23
Summary
Predicted to be involved in protein targeting to ER and signal peptide processing. Predicted to be located in membrane. Predicted to be part of signal peptidase complex. Is expressed in several structures, including adult head; adult heart; border follicle cell; egg chamber; and gland. Orthologous to human SPCS3 (signal peptidase complex subunit 3). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See Spase22-23 in Genome Data Viewer
Location:
95F3-95F3; 3-84 cM
Exon count:
1
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (24228342..24230035, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (20054064..20055757, complement)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene twin Neighboring gene uncharacterized protein Neighboring gene caravaggio Neighboring gene long non-coding RNA:CR45217 Neighboring gene Sp1-like factor for pairing sensitive-silencing Neighboring gene long non-coding RNA:CR44092 Neighboring gene uncharacterized protein Neighboring gene Accessory gland protein 95EF Neighboring gene small Cajal body-specific RNA : MeU2-G25 Neighboring gene multiple ankyrin repeats single KH domain

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Analysis of the functions of the signal peptidase complex in the midgut of Tribolium castaneum. Guan J, et al. Arch Insect Biochem Physiol, 2018 Mar. PMID 29265467
  2. A CRISPR screen defines a signal peptide processing pathway required by flaviviruses. Zhang R, et al. Nature, 2016 Jul 7. PMID 27383988, Free PMC Article
  3. Drosophila signal peptidase complex member Spase12 is required for development and cell differentiation. Haase Gilbert E, et al. PLoS One, 2013. PMID 23573290, Free PMC Article
  4. Spatial specificity of mesodermal even-skipped expression relies on multiple repressor sites. Liu J, et al. Dev Biol, 2008 Jan 15. PMID 18067885, Free PMC Article
  5. A hormonal cue promotes timely follicle cell migration by modulating transcription profiles. Manning L, et al. Mech Dev, 2017 Dec. PMID 28610887, Free PMC Article

See all (41) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Process Evidence Code Pubs
involved_in protein targeting to ER IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in signal peptide processing IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in signal peptide processing IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
part_of signal peptidase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of signal peptidase complex IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
spase 22/23-subunit
Names
CG5677-PA
CG5677-PB
Spase22-23-PA
Spase22-23-PB
Spase22/23-subunit

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    24228342..24230035 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001260350.2 → NP_001247279.1  spase 22/23-subunit, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001247279.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9VCA9
    UniProtKB/TrEMBL
    A0A0B4K7R1
    Conserved Domains (1) summary
    pfam04573
    Location:4 → 172
    SPC22; Signal peptidase subunit

  2. NM_142977.5 → NP_651234.1  spase 22/23-subunit, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_651234.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9VCA9
    UniProtKB/TrEMBL
    A0A0B4K7R1
    Related
    FBpp0083949
    Conserved Domains (1) summary
    pfam04573
    Location:4 → 172
    SPC22; Signal peptidase subunit
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A0B4K7R1 A0A0B4K7R1
Q9VCA9.1 Q9VCA9

Gene LinkOut

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