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Uck Uridine-cytidine kinase [ Drosophila melanogaster (fruit fly) ]

Gene ID: 42894, updated on 4-Jan-2025

Summary

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Official Symbol
Uckprovided by FlyBase
Official Full Name
Uridine-cytidine kinaseprovided by FlyBase
Primary source
FLYBASE:FBgn0263398
Locus tag
Dmel_CG6364
See related
AllianceGenome:FB:FBgn0263398
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG6364; CR42873; Dmel\CG6364; Uck2
Old locus tag
Dmel_CR42873
Summary
Predicted to enable cytidine kinase activity and uridine kinase activity. Predicted to be active in cytoplasm. Is expressed in several structures, including adult head; embryonic/larval midgut primordium; gland; gut section; and salivary gland body primordium. Orthologous to several human genes including UCK1 (uridine-cytidine kinase 1). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
all
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Genomic context

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See Uck in Genome Data Viewer
Location:
95F10-95F10; 3-84 cM
Exon count:
8
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (24290172..24293371)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (20115894..20119093)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR45662 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene crumbs Neighboring gene Nuclear polyadenosine RNA-binding 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Ehrlichia chaffeensis replication sites in adult Drosophila melanogaster. Drolia R, et al. Int J Med Microbiol, 2013 Jan. PMID 23306065, Free PMC Article
  2. Severe Fertility Effects of sheepish Sperm Caused by Failure To Enter Female Sperm Storage Organs in Drosophila melanogaster. Tomaru M, et al. G3 (Bethesda), 2018 Jan 4. PMID 29158336, Free PMC Article
  3. Transcripts immunoprecipitated with Sxl protein in primordial germ cells of Drosophila embryos. Ota R, et al. Dev Growth Differ, 2017 Dec. PMID 29124738
  4. Identification of critical host mitochondrion-associated genes during Ehrlichia chaffeensis infections. Von Ohlen T, et al. Infect Immun, 2012 Oct. PMID 22851751, Free PMC Article
  5. Ribbon regulates morphogenesis of the Drosophila embryonic salivary gland through transcriptional activation and repression. Loganathan R, et al. Dev Biol, 2016 Jan 1. PMID 26477561, Free PMC Article

See all (35) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables cytidine kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables uridine kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Uridine-cytidine kinase
Names
CG6364-PA
CG6364-PB
CG6364-PC
CG6364-PD
CG6364-PE
Uck-PA
Uck-PB
Uck-PC
Uck-PD
Uck-PE
NP_001138105.1
NP_001247281.1
NP_001247282.1
NP_001247283.1
NP_651241.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    24290172..24293371
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001260352.2 → NP_001247281.1  Uridine-cytidine kinase, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001247281.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    H1UUH6, Q9VC99
    UniProtKB/TrEMBL
    Q8MRJ1
    Conserved Domains (1) summary
    cd02023
    Location:29 → 236
    UMPK; Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway, ...

  2. NM_001144633.3 → NP_001138105.1  Uridine-cytidine kinase, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001138105.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    B7Z0P8, Q8MRJ1
    Conserved Domains (1) summary
    cd02023
    Location:29 → 235
    UMPK; Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway, ...

  3. NM_001260353.2 → NP_001247282.1  Uridine-cytidine kinase, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001247282.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    H1UUH6, Q9VC99
    UniProtKB/TrEMBL
    Q8MRJ1
    Conserved Domains (1) summary
    cd02023
    Location:29 → 236
    UMPK; Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway, ...

  4. NM_001260354.2 → NP_001247283.1  Uridine-cytidine kinase, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001247283.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    H1UUH6, Q9VC99
    UniProtKB/TrEMBL
    Q8MRJ1
    Conserved Domains (1) summary
    cd02023
    Location:29 → 236
    UMPK; Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway, ...

  5. NM_142984.2 → NP_651241.1  Uridine-cytidine kinase, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_651241.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    H1UUH6, Q9VC99
    UniProtKB/TrEMBL
    Q8MRJ1
    Related
    FBpp0083986
    Conserved Domains (1) summary
    cd02023
    Location:29 → 236
    UMPK; Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway, ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
B7Z0P8 B7Z0P8
Q8MRJ1 Q8MRJ1
Q9VC99.1 Q9VC99

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