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Dis3 Dis3 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 42900, updated on 9-Dec-2024

Summary

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Official Symbol
Dis3provided by FlyBase
Official Full Name
Dis3provided by FlyBase
Primary source
FLYBASE:FBgn0039183
Locus tag
Dmel_CG6413
See related
AllianceGenome:FB:FBgn0039183
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG6413; dDis3; dis3; Dmel\CG6413; dRrp44; Rrp44; taz; Taz
Summary
Enables RNA endonuclease activity and RNA exonuclease activity. Involved in several processes, including defense response to virus; mitotic cell cycle; and nuclear RNA surveillance. Located in nuclear lamina. Part of nuclear exosome (RNase complex). Is expressed in adult head; mesoderm; nurse cell; oocyte; and organism. Used to study multiple myeloma and primary ovarian insufficiency. Orthologous to human DIS3 (DIS3 homolog, exosome endoribonuclease and 3'-5' exoribonuclease). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See Dis3 in Genome Data Viewer
Location:
95F13-95F14; 3-84 cM
Exon count:
5
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (24333433..24337248)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (20159155..20162970)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene antisense RNA:CR46093 Neighboring gene BRWD3 Neighboring gene Ribosomal RNA Processing 5 Neighboring gene uncharacterized protein Neighboring gene mir-1015 stem loop Neighboring gene Myosuppressin

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Drosophila gene tazman, an orthologue of the yeast exosome component Rrp44p/Dis3, is differentially expressed during development. Cairrão F, et al. Dev Dyn, 2005 Mar. PMID 15704111
  2. DIS3 Variants are Associated With Primary Ovarian Insufficiency: Importance of Transcription/Translation in Oogenesis. Johnstone EB, et al. J Clin Endocrinol Metab, 2023 Aug 18. PMID 36869713, Free PMC Article
  3. The 3' to 5' Exoribonuclease DIS3: From Structure and Mechanisms to Biological Functions and Role in Human Disease. Robinson SR, et al. Biomolecules, 2015 Jul 17. PMID 26193331, Free PMC Article
  4. Characterization of the Drosophila melanogaster Dis3 ribonuclease. Mamolen M, et al. Biochem Biophys Res Commun, 2009 Dec 18. PMID 19800864, Free PMC Article
  5. The ribonuclease Dis3 is an essential regulator of the developmental transcriptome. Hou D, et al. BMC Genomics, 2012 Aug 1. PMID 22853036, Free PMC Article

See all (69) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. DIS3 Variants are Associated With Primary Ovarian Insufficiency: Importance of Transcription/Translation in Oogenesis.
    Title: DIS3 Variants are Associated With Primary Ovarian Insufficiency: Importance of Transcription/Translation in Oogenesis.
  2. Use of RNA-seq to quantify the effect of Dis3 knockdown on microRNA expression shows that Dis3 normally regulates a small subset of microRNAs, with only 11 increasing in level >/= 2-fold and 6 decreasing in level >/= 2-fold.
    Title: The 3'-5' exoribonuclease Dis3 regulates the expression of specific microRNAs in Drosophila wing imaginal discs.
  3. Dis3 is essential for early Drosophila melanogaster development.
    Title: The ribonuclease Dis3 is an essential regulator of the developmental transcriptome.
  4. the dDis3 N-terminus is sufficient for endoribonuclease activity in vitro and that proper N-terminal domain structure is critical for activity of the full-length polypeptide.
    Title: Drosophila melanogaster Dis3 N-terminal domains are required for ribonuclease activities, nuclear localization and exosome interactions.
  5. Genome-wide analysis reveals distinct substrate specificities of Dis3, and core exosome subunits
    Title: Genome-wide analysis reveals distinct substrate specificities of Rrp6, Dis3, and core exosome subunits.
  6. this study broadens our mechanistic understanding of the general ribonuclease activity of Dis3 and RNR family members.
    Title: Characterization of the Drosophila melanogaster Dis3 ribonuclease.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables 3'-5'-RNA exonuclease activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables RNA endonuclease activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables RNA exonuclease activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables RNA nuclease activity IEA
Inferred from Electronic Annotation
more info
  
enables endonuclease activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in defense response to virus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mitotic cell cycle IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in nuclear RNA surveillance IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in nuclear mRNA surveillance of mRNA 3'-end processing IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in rRNA catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of cytoplasmic exosome (RNase complex) IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of exosome (RNase complex) IDA
Inferred from Direct Assay
more info
 PubMed 
part_of nuclear exosome (RNase complex) IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of nuclear exosome (RNase complex) IDA
Inferred from Direct Assay
more info
 PubMed 
part_of nuclear exosome (RNase complex) ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
located_in nuclear lamina IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
Dis3
Names
CG6413-PA
CG6413-PB
Dis3 ribonuclease
Dis3-PA
Dis3-PB
tazman
NP_001262910.1
NP_651246.2

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    24333433..24337248
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_142989.4 → NP_651246.2  Dis3, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_651246.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q960A7, Q9VC93
    Related
    FBpp0083989
    Conserved Domains (3) summary
    cd09862
    Location:9 → 203
    PIN_Rrp44; PIN domain of yeast exosome subunit Rrp44 endoribonuclease and other eukaryotic homologs
    COG0557
    Location:249 → 945
    VacB; Exoribonuclease R [Transcription]
    pfam00773
    Location:474 → 802
    RNB; RNB domain

  2. NM_001275981.1 → NP_001262910.1  Dis3, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001262910.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q960A7, Q9VC93
    Conserved Domains (3) summary
    cd09862
    Location:9 → 203
    PIN_Rrp44; PIN domain of yeast exosome subunit Rrp44 endoribonuclease and other eukaryotic homologs
    COG0557
    Location:249 → 945
    VacB; Exoribonuclease R [Transcription]
    pfam00773
    Location:474 → 802
    RNB; RNB domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8MSY2 Q8MSY2
Q960A7 Q960A7
Q9BI20 Q9BI20
Q9VC93 Q9VC93

Gene LinkOut

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