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RAPGEF4 Rap guanine nucleotide exchange factor 4 [ Gallus gallus (chicken) ]

Gene ID: 429022, updated on 3-Dec-2024

Summary

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Official Symbol
RAPGEF4provided by CGNC
Official Full Name
Rap guanine nucleotide exchange factor 4provided by CGNC
Primary source
CGNC:7114
See related
Ensembl:ENSGALG00010021781
Gene type
protein coding
RefSeq status
MODEL
Organism
Gallus gallus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Orthologs
human mouse all
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Genomic context

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See RAPGEF4 in Genome Data Viewer
Location:
chromosome: 7
Exon count:
35
Annotation release Status Assembly Chr Location
106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 7 NC_052538.1 (17063151..17207736, complement)
106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 7 NC_052579.1 (16980418..17125104, complement)

Chromosome 7 - NC_052538.1Genomic Context describing neighboring genes Neighboring gene cell division cycle associated 7 Neighboring gene mitogen-activated protein kinase kinase kinase 20 Neighboring gene protein phosphatase 1 regulatory subunit 9 like Neighboring gene uncharacterized LOC101748000 Neighboring gene pyruvate dehydrogenase kinase 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables guanyl-nucleotide exchange factor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in Ras protein signal transduction IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of GTPase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
rap guanine nucleotide exchange factor 4
Names
Rap guanine nucleotide exchange factor (GEF) 4

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

  1. NC_052538.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Range
    17063151..17207736 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_025152580.3 → XP_025008348.1  rap guanine nucleotide exchange factor 4 isoform X3

    UniProtKB/TrEMBL
    A0A1D5NVU8, A0A8V0ZM50
    Related
    ENSGALP00010031902.1, ENSGALT00010052996.1
    Conserved Domains (4) summary
    smart00147
    Location:734 → 975
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    cd00038
    Location:322 → 433
    CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
    cd04437
    Location:172 → 300
    DEP_Epac; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in Epac-like proteins. Epac (exchange proteins directly activated by cAMP) proteins are GEFs (guanine-nucleotide-exchange factors) for the small GTPases, Rap1 and Rap2. They are directly regulated by ...
    pfam00618
    Location:465 → 571
    RasGEF_N; RasGEF N-terminal motif

  2. XM_025152579.3 → XP_025008347.1  rap guanine nucleotide exchange factor 4 isoform X2

    UniProtKB/TrEMBL
    A0A8V0ZKI7, A0A8V0ZM50
    Related
    ENSGALP00010031906.1, ENSGALT00010053000.1
    Conserved Domains (4) summary
    smart00147
    Location:765 → 1006
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    cd00038
    Location:43 → 154
    CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
    cd04437
    Location:203 → 331
    DEP_Epac; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in Epac-like proteins. Epac (exchange proteins directly activated by cAMP) proteins are GEFs (guanine-nucleotide-exchange factors) for the small GTPases, Rap1 and Rap2. They are directly regulated by ...
    pfam00618
    Location:496 → 602
    RasGEF_N; RasGEF N-terminal motif

  3. XM_025152581.3 → XP_025008349.1  rap guanine nucleotide exchange factor 4 isoform X1

    UniProtKB/TrEMBL
    A0A1D5PMC0, A0A8V0ZM50
    Related
    ENSGALP00010031894.1, ENSGALT00010052988.1
    Conserved Domains (4) summary
    smart00147
    Location:783 → 1024
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    cd00038
    Location:43 → 154
    CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
    cd04437
    Location:221 → 349
    DEP_Epac; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in Epac-like proteins. Epac (exchange proteins directly activated by cAMP) proteins are GEFs (guanine-nucleotide-exchange factors) for the small GTPases, Rap1 and Rap2. They are directly regulated by ...
    pfam00618
    Location:514 → 620
    RasGEF_N; RasGEF N-terminal motif

  4. XM_040704339.1 → XP_040560273.1  rap guanine nucleotide exchange factor 4 isoform X5

    UniProtKB/TrEMBL
    A0A8V0ZF43, A0A8V0ZMF3
    Related
    ENSGALP00010031915.1, ENSGALT00010053009.1
    Conserved Domains (4) summary
    smart00147
    Location:606 → 847
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    cd00038
    Location:194 → 305
    CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
    cd04437
    Location:64 → 172
    DEP_Epac; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in Epac-like proteins. Epac (exchange proteins directly activated by cAMP) proteins are GEFs (guanine-nucleotide-exchange factors) for the small GTPases, Rap1 and Rap2. They are directly regulated by ...
    pfam00618
    Location:337 → 443
    RasGEF_N; RasGEF N-terminal motif

  5. XM_025152583.3 → XP_025008351.1  rap guanine nucleotide exchange factor 4 isoform X5

    UniProtKB/TrEMBL
    A0A8V0ZF43, A0A8V0ZMF3
    Conserved Domains (4) summary
    smart00147
    Location:606 → 847
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    cd00038
    Location:194 → 305
    CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
    cd04437
    Location:64 → 172
    DEP_Epac; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in Epac-like proteins. Epac (exchange proteins directly activated by cAMP) proteins are GEFs (guanine-nucleotide-exchange factors) for the small GTPases, Rap1 and Rap2. They are directly regulated by ...
    pfam00618
    Location:337 → 443
    RasGEF_N; RasGEF N-terminal motif

  6. XM_015289610.4 → XP_015145096.2  rap guanine nucleotide exchange factor 4 isoform X4

    UniProtKB/TrEMBL
    A0A8V0ZM50
    Related
    ENSGALP00010031888.1, ENSGALT00010052982.1
    Conserved Domains (4) summary
    smart00147
    Location:630 → 871
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    cd00038
    Location:218 → 329
    CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
    cd04437
    Location:68 → 196
    DEP_Epac; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in Epac-like proteins. Epac (exchange proteins directly activated by cAMP) proteins are GEFs (guanine-nucleotide-exchange factors) for the small GTPases, Rap1 and Rap2. They are directly regulated by ...
    pfam00618
    Location:361 → 467
    RasGEF_N; RasGEF N-terminal motif

  7. XM_015289609.4 → XP_015145095.2  rap guanine nucleotide exchange factor 4 isoform X4

    UniProtKB/TrEMBL
    A0A8V0ZM50
    Related
    ENSGALP00010031882.1, ENSGALT00010052976.1
    Conserved Domains (4) summary
    smart00147
    Location:630 → 871
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    cd00038
    Location:218 → 329
    CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
    cd04437
    Location:68 → 196
    DEP_Epac; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in Epac-like proteins. Epac (exchange proteins directly activated by cAMP) proteins are GEFs (guanine-nucleotide-exchange factors) for the small GTPases, Rap1 and Rap2. They are directly regulated by ...
    pfam00618
    Location:361 → 467
    RasGEF_N; RasGEF N-terminal motif

  8. XM_046944059.1 → XP_046800015.1  rap guanine nucleotide exchange factor 4 isoform X7

    UniProtKB/TrEMBL
    A0A8V0ZMF3

  9. XM_046944058.1 → XP_046800014.1  rap guanine nucleotide exchange factor 4 isoform X6

    UniProtKB/TrEMBL
    A0A8V0ZMF3

RNA

  1. XR_005861769.2 RNA Sequence

  2. XR_005861770.2 RNA Sequence

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

  1. NC_052579.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Range
    16980418..17125104 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_040677009.2 → XP_040532943.1  rap guanine nucleotide exchange factor 4 isoform X3

    UniProtKB/TrEMBL
    A0A1D5NVU8, A0A8V0ZM50
    Conserved Domains (4) summary
    smart00147
    Location:734 → 975
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    cd00038
    Location:322 → 433
    CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
    cd04437
    Location:172 → 300
    DEP_Epac; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in Epac-like proteins. Epac (exchange proteins directly activated by cAMP) proteins are GEFs (guanine-nucleotide-exchange factors) for the small GTPases, Rap1 and Rap2. They are directly regulated by ...
    pfam00618
    Location:465 → 571
    RasGEF_N; RasGEF N-terminal motif

  2. XM_040677008.2 → XP_040532942.1  rap guanine nucleotide exchange factor 4 isoform X2

    UniProtKB/TrEMBL
    A0A8V0ZKI7, A0A8V0ZM50
    Conserved Domains (4) summary
    smart00147
    Location:765 → 1006
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    cd00038
    Location:43 → 154
    CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
    cd04437
    Location:203 → 331
    DEP_Epac; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in Epac-like proteins. Epac (exchange proteins directly activated by cAMP) proteins are GEFs (guanine-nucleotide-exchange factors) for the small GTPases, Rap1 and Rap2. They are directly regulated by ...
    pfam00618
    Location:496 → 602
    RasGEF_N; RasGEF N-terminal motif

  3. XM_040677007.2 → XP_040532941.1  rap guanine nucleotide exchange factor 4 isoform X1

    UniProtKB/TrEMBL
    A0A1D5PMC0, A0A8V0ZM50
    Conserved Domains (4) summary
    smart00147
    Location:783 → 1024
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    cd00038
    Location:43 → 154
    CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
    cd04437
    Location:221 → 349
    DEP_Epac; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in Epac-like proteins. Epac (exchange proteins directly activated by cAMP) proteins are GEFs (guanine-nucleotide-exchange factors) for the small GTPases, Rap1 and Rap2. They are directly regulated by ...
    pfam00618
    Location:514 → 620
    RasGEF_N; RasGEF N-terminal motif

  4. XM_040677013.1 → XP_040532947.1  rap guanine nucleotide exchange factor 4 isoform X5

    UniProtKB/TrEMBL
    A0A8V0ZF43, A0A8V0ZMF3
    Conserved Domains (4) summary
    smart00147
    Location:606 → 847
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    cd00038
    Location:194 → 305
    CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
    cd04437
    Location:64 → 172
    DEP_Epac; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in Epac-like proteins. Epac (exchange proteins directly activated by cAMP) proteins are GEFs (guanine-nucleotide-exchange factors) for the small GTPases, Rap1 and Rap2. They are directly regulated by ...
    pfam00618
    Location:337 → 443
    RasGEF_N; RasGEF N-terminal motif

  5. XM_040677014.2 → XP_040532948.1  rap guanine nucleotide exchange factor 4 isoform X5

    UniProtKB/TrEMBL
    A0A8V0ZF43, A0A8V0ZMF3
    Conserved Domains (4) summary
    smart00147
    Location:606 → 847
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    cd00038
    Location:194 → 305
    CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
    cd04437
    Location:64 → 172
    DEP_Epac; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in Epac-like proteins. Epac (exchange proteins directly activated by cAMP) proteins are GEFs (guanine-nucleotide-exchange factors) for the small GTPases, Rap1 and Rap2. They are directly regulated by ...
    pfam00618
    Location:337 → 443
    RasGEF_N; RasGEF N-terminal motif

  6. XM_040677012.2 → XP_040532946.1  rap guanine nucleotide exchange factor 4 isoform X4

    UniProtKB/TrEMBL
    A0A8V0ZM50
    Conserved Domains (4) summary
    smart00147
    Location:630 → 871
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    cd00038
    Location:218 → 329
    CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
    cd04437
    Location:68 → 196
    DEP_Epac; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in Epac-like proteins. Epac (exchange proteins directly activated by cAMP) proteins are GEFs (guanine-nucleotide-exchange factors) for the small GTPases, Rap1 and Rap2. They are directly regulated by ...
    pfam00618
    Location:361 → 467
    RasGEF_N; RasGEF N-terminal motif

  7. XM_040677011.2 → XP_040532945.1  rap guanine nucleotide exchange factor 4 isoform X4

    UniProtKB/TrEMBL
    A0A8V0ZM50
    Conserved Domains (4) summary
    smart00147
    Location:630 → 871
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    cd00038
    Location:218 → 329
    CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
    cd04437
    Location:68 → 196
    DEP_Epac; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in Epac-like proteins. Epac (exchange proteins directly activated by cAMP) proteins are GEFs (guanine-nucleotide-exchange factors) for the small GTPases, Rap1 and Rap2. They are directly regulated by ...
    pfam00618
    Location:361 → 467
    RasGEF_N; RasGEF N-terminal motif

  8. XM_046921927.1 → XP_046777883.1  rap guanine nucleotide exchange factor 4 isoform X7

    UniProtKB/TrEMBL
    A0A8V0ZMF3

  9. XM_046921926.1 → XP_046777882.1  rap guanine nucleotide exchange factor 4 isoform X6

    UniProtKB/TrEMBL
    A0A8V0ZMF3

RNA

  1. XR_005852018.2 RNA Sequence

  2. XR_005852019.2 RNA Sequence

Nucleotide Protein
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