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CG6454 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

Gene ID: 42904, updated on 9-Dec-2024

Summary

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Official Symbol
CG6454provided by FlyBase
Official Full Name
uncharacterized proteinprovided by FlyBase
Primary source
FLYBASE:FBgn0039187
Locus tag
Dmel_CG6454
See related
AllianceGenome:FB:FBgn0039187
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
Dmel\CG6454
Summary
Predicted to enable calcium ion binding activity and calcium-dependent phospholipid binding activity. Predicted to be involved in several processes, including intracellular protein transmembrane transport; positive regulation of protein targeting to membrane; and positive regulation of transport. Predicted to be active in plasma membrane. Is expressed in adult head. Orthologous to human C2CD5 (C2 calcium dependent domain containing 5). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
all
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Genomic context

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See CG6454 in Genome Data Viewer
Location:
95F14-95F15; 3-84 cM
Exon count:
11
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (24349182..24356241)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (20174904..20181963)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Myosuppressin Neighboring gene uncharacterized protein Neighboring gene Golgin-84 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Genetic and molecular analysis of the synaptotagmin family. Adolfsen B, et al. Cell Mol Life Sci, 2001 Mar. PMID 11315187, Free PMC Article
  2. Drosophila Insulin-Like Peptides DILP2 and DILP5 Differentially Stimulate Cell Signaling and Glycogen Phosphorylase to Regulate Longevity. Post S, et al. Front Endocrinol (Lausanne), 2018. PMID 29892262, Free PMC Article
  3. Genome-wide identification of alternative splice forms down-regulated by nonsense-mediated mRNA decay in Drosophila. Hansen KD, et al. PLoS Genet, 2009 Jun. PMID 19543372, Free PMC Article
  4. Chromosomal rearrangement inferred from comparisons of 12 Drosophila genomes. Bhutkar A, et al. Genetics, 2008 Jul. PMID 18622036, Free PMC Article
  5. Analysis of the expression patterns, subcellular localisations and interaction partners of Drosophila proteins using a pigP protein trap library. Lowe N, et al. Development, 2014 Oct. PMID 25294943, Free PMC Article

See all (28) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables calcium ion binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables calcium-dependent phospholipid binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables calcium-dependent phospholipid binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in intracellular protein transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of D-glucose transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of protein targeting to membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of vesicle fusion IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein localization to plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
uncharacterized protein
Names
CG6454-PC
CG6454-PD
CG6454-PE
CG6454-PF

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    24349182..24356241
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_142992.3 → NP_651249.2  uncharacterized protein Dmel_CG6454, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_651249.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8IMW9
    Conserved Domains (1) summary
    cd08688
    Location:5 → 121
    C2_KIAA0528-like; C2 domain found in the Human KIAA0528 cDNA clone

  2. NM_001414141.1 → NP_001401047.1  uncharacterized protein Dmel_CG6454, isoform F [Drosophila melanogaster]

    Status: REVIEWED

  3. NM_001275986.1 → NP_001262915.1  uncharacterized protein Dmel_CG6454, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001262915.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4KGY2
    Conserved Domains (1) summary
    cd08688
    Location:5 → 121
    C2_KIAA0528-like; C2 domain found in the Human KIAA0528 cDNA clone

  4. NM_170141.3 → NP_732985.2  uncharacterized protein Dmel_CG6454, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_732985.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VC89
    Conserved Domains (1) summary
    cd08688
    Location:5 → 121
    C2_KIAA0528-like; C2 domain found in the Human KIAA0528 cDNA clone
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A0B4KGY2 A0A0B4KGY2
Q8IMW9 Q8IMW9
Q8MR20 Q8MR20
Q9VC89 Q9VC89

Gene LinkOut

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