Pp1alpha-96A Protein phosphatase 1alpha at 96A [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Pp1alpha-96Aprovided by FlyBase
Official Full Name: Protein phosphatase 1alpha at 96Aprovided by FlyBase
Primary source: FLYBASE:FBgn0003134
Locus tag: Dmel_CG6593
See related: AllianceGenome:FB:FBgn0003134
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: 96A; CG6593; Dmel\CG6593; DmPp1-96A; PP1; PP1 96A; PP1 alpha96a; Pp1-96A; PP1-96A; PP1A-96A; PP1alpha; pp1alpha-96A; PP1alpha-96A; pp1alpha96A; PP1alpha96A; PP1alpha[[1]]; PP1c; PP1c 96A
Summary: Predicted to enable protein serine/threonine phosphatase activity. Involved in negative regulation of smoothened signaling pathway and positive regulation of canonical Wnt signaling pathway. Located in cytoplasm. Part of protein phosphatase type 1 complex. Is expressed in adult head and organism. Orthologous to human PPP1CA (protein phosphatase 1 catalytic subunit alpha). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 96A5-96A5; 3-85 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (24518270..24522331)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3R	NT_033777.2 (20343992..20348053)

Chromosome 3R - NT_033777.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Overexpression of the PP1 alpha isozymes does not rescue semilethal PP1 beta 9C mutants, whereas overexpression of either PP1 alpha 96A or PP1 beta 9C does rescue a lethal PP1 alpha 87B mutant combination.
Title: Essential, overlapping and redundant roles of the Drosophila protein phosphatase 1 alpha and 1 beta genes.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine phosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein serine/threonine phosphatase activity	ISM Inferred from Sequence Model more info	PubMed

Process	Evidence Code	Pubs
involved_in defense response to Gram-negative bacterium	HMP more info	PubMed
involved_in negative regulation of BMP signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of smoothened signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of canonical Wnt signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of innate immune response	HMP more info	PubMed
involved_in regulation of glycogen biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of glycogen catabolic process	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in cytoplasm	HDA more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
part_of protein phosphatase type 1 complex	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: protein phosphatase 1alpha at 96A

Names: CG6593-PA; CG6593-PB; Pp1alpha-96A-PA; Pp1alpha-96A-PB; protein phosphatase 1

NP_001262919.1

EC 3.-.-.-

EC 3.1.3.16

NP_524484.1

EC 3.-.-.-

EC 3.1.3.16

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033777.3 Reference assembly

Range

24518270..24522331

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001275990.1 → NP_001262919.1 protein phosphatase 1alpha at 96A, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001262919.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P48461, Q5U0Y2, Q9VC69

UniProtKB/TrEMBL

A0A0B4KHS9, C0MKX3

Conserved Domains (1) summary

cd07414
Location:6 → 296

MPP_PP1_PPKL; PP1, PPKL (PP1 and kelch-like) enzymes, and related proteins, metallophosphatase domain
NM_079760.3 → NP_524484.1 protein phosphatase 1alpha at 96A, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_524484.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P48461, Q5U0Y2, Q9VC69

UniProtKB/TrEMBL

A0A0B4KHS9, C0MKX3

Related

FBpp0084026

Conserved Domains (1) summary

cd07414
Location:6 → 296

MPP_PP1_PPKL; PP1, PPKL (PP1 and kelch-like) enzymes, and related proteins, metallophosphatase domain