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CG13630 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

Gene ID: 42943, updated on 9-Dec-2024

Summary

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Official Symbol
CG13630provided by FlyBase
Official Full Name
uncharacterized proteinprovided by FlyBase
Primary source
FLYBASE:FBgn0039219
Locus tag
Dmel_CG13630
See related
AllianceGenome:FB:FBgn0039219
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
Dmel\CG13630; MAP1A
Summary
Predicted to enable metalloaminopeptidase activity. Predicted to be involved in proteolysis. Predicted to be active in cytosol. Is expressed in adult head. Orthologous to human METAP1 (methionyl aminopeptidase 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See CG13630 in Genome Data Viewer
Location:
96A18-96A18; 3-85 cM
Exon count:
3
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (24717937..24719364, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (20543659..20545086, complement)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene slowpoke Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene RNA polymerase II, I and III subunit L Neighboring gene tolkin Neighboring gene tolloid

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Identification of eukaryotic peptide deformylases reveals universality of N-terminal protein processing mechanisms. Giglione C, et al. EMBO J, 2000 Nov 1. PMID 11060042, Free PMC Article
  2. Proteogenomics of Adenosine-to-Inosine RNA Editing in the Fruit Fly. Kuznetsova KG, et al. J Proteome Res, 2018 Nov 2. PMID 30298734
  3. Comparative genome and proteome analysis of Anopheles gambiae and Drosophila melanogaster. Zdobnov EM, et al. Science, 2002 Oct 4. PMID 12364792
  4. Activation of Smurf E3 ligase promoted by smoothened regulates hedgehog signaling through targeting patched turnover. Huang S, et al. PLoS Biol, 2013 Nov. PMID 24302888, Free PMC Article
  5. Loss of PAFAH1B2 reduces amyloid-β generation by promoting the degradation of amyloid precursor protein C-terminal fragments. Page RM, et al. J Neurosci, 2012 Dec 12. PMID 23238734, Free PMC Article

See all (32) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables metalloaminopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metalloaminopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
uncharacterized protein
Names
CG13630-PA

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    24717937..24719364 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_143024.3 → NP_651281.1  uncharacterized protein Dmel_CG13630 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_651281.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VC48
    Related
    FBpp0084120
    Conserved Domains (3) summary
    PLN03158
    Location:10 → 369
    PLN03158; methionine aminopeptidase; Provisional
    cd01086
    Location:123 → 360
    MetAP1; Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.
    pfam15801
    Location:9 → 48
    zf-C6H2; zf-MYND-like zinc finger, mRNA-binding
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VC48 Q9VC48

Gene LinkOut

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