tld - tolloid

Enables collagen binding activity and metalloendopeptidase activity. Involved in several processes, including R8 cell fate specification; amnioserosa formation; and positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway. Located in extracellular space. Is expressed in several structures, including anlage in statu nascendi; embryonic gnathal segment; epithelium; head epidermis primordium; and imaginal disc. Human ortholog(s) of this gene implicated in atrial heart septal defect 6; congenital heart disease; and coronary artery disease. Orthologous to human TLL1 (tolloid like 1). [provided by Alliance of Genome Resources, Dec 2024]

NCBI Orthologs

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