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polybromo - polybromo

Predicted to enable chromatin binding activity. Involved in cellular component assembly involved in morphogenesis; chromatin remodeling; and negative regulation of transcription by RNA polymerase II. Part of brahma complex. Is expressed in several structures, including central brain primordium; embryonic/larval midgut; ganglia; and ventral nerve cord primordium. Human ortholog(s) of this gene implicated in extrahepatic bile duct adenocarcinoma; lung non-small cell carcinoma; lung small cell carcinoma; and renal cell carcinoma. Orthologous to human PBRM1 (polybromo 1). [provided by Alliance of Genome Resources, Dec 2024]

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Species Gene Architecture aa