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niki nimA-like kinase [ Drosophila melanogaster (fruit fly) ]

Gene ID: 42959, updated on 9-Dec-2024

Summary

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Official Symbol
nikiprovided by FlyBase
Official Full Name
nimA-like kinaseprovided by FlyBase
Primary source
FLYBASE:FBgn0045980
Locus tag
Dmel_CG10951
See related
AllianceGenome:FB:FBgn0045980
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG10951; Dmel\CG10951; NEK1; Niki
Summary
Predicted to enable protein serine/threonine kinase activity. Predicted to be located in cilium. Predicted to be active in nucleus. Used to study amyotrophic lateral sclerosis type 24. Human ortholog(s) of this gene implicated in lethal congenital contracture syndrome; nephronophthisis 9; and renal-hepatic-pancreatic dysplasia. Orthologous to several human genes including NEK9 (NIMA related kinase 9). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
all
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Genomic context

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See niki in Genome Data Viewer
Location:
96A23-96A24; 3-85 cM
Exon count:
9
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (24822401..24825648, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (20648123..20651370, complement)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene antisense RNA:CR46096 Neighboring gene uncharacterized protein Neighboring gene Scaffold attachment factor B Neighboring gene long non-coding RNA:CR43166 Neighboring gene RabX4 Neighboring gene Katazuke

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Loss of function of the ALS-associated NEK1 kinase disrupts microtubule homeostasis and nuclear import. Mann JR, et al. Sci Adv, 2023 Aug 18. PMID 37585529, Free PMC Article
  2. High-resolution SNP mapping by denaturing HPLC. Nairz K, et al. Proc Natl Acad Sci U S A, 2002 Aug 6. PMID 12149455, Free PMC Article
  3. Drosophila Nek2 protein kinase knockdown leads to centrosome maturation defects while overexpression causes centrosome fragmentation and cytokinesis failure. Prigent C, et al. Exp Cell Res, 2005 Feb 1. PMID 15572022
  4. A migrating ciliary gate compartmentalizes the site of axoneme assembly in Drosophila spermatids. Basiri ML, et al. Curr Biol, 2014 Nov 17. PMID 25447994, Free PMC Article
  5. Nicastrin controls aspects of photoreceptor neuron specification and differentiation in the Drosophila eye. Zhang T, et al. Dev Dyn, 2005 Nov. PMID 16145661

See all (34) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein serine/threonine kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cilium ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
nimA-like kinase
Names
CG10951-PA
niki-PA
NP_651293.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    24822401..24825648 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_143036.2 → NP_651293.1  nimA-like kinase [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_651293.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VC32
    Related
    FBpp0084112
    Conserved Domains (3) summary
    smart00220
    Location:105 → 354
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    COG5184
    Location:445 → 747
    ATS1; Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
    cd08215
    Location:104 → 359
    STKc_Nek; Catalytic domain of the Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VC32 Q9VC32

Gene LinkOut

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