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Trf4-2 Topoisomerase related function 4-2 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 42983, updated on 9-Dec-2024

Summary

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Official Symbol
Trf4-2provided by FlyBase
Official Full Name
Topoisomerase related function 4-2provided by FlyBase
Primary source
FLYBASE:FBgn0039251
Locus tag
Dmel_CG17462
See related
AllianceGenome:FB:FBgn0039251
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
AAF56369; CG17462; Dmel\CG17462; DmTRF4-2
Summary
Predicted to enable poly(A) RNA polymerase activity. Predicted to be involved in RNA 3'-end processing; nuclear polyadenylation-dependent ncRNA catabolic process; and polyadenylation-dependent ncRNA catabolic process. Predicted to be part of TRAMP complex. Predicted to be active in nucleolus. Is expressed in organism and spermatozoon. Orthologous to human TENT4A (terminal nucleotidyltransferase 4A). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See Trf4-2 in Genome Data Viewer
Location:
96B9-96B9; 3-86 cM
Exon count:
1
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (24925216..24927085)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (20750938..20752807)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene antisense RNA:CR46097 Neighboring gene Mitotic spindle and nuclear protein Neighboring gene uncharacterized protein Neighboring gene Oxysterol binding protein Neighboring gene slingshot

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Evolution of miRNA Tailing by 3' Terminal Uridylyl Transferases in Metazoa. Modepalli V, et al. Genome Biol Evol, 2017 Jun 1. PMID 28633361, Free PMC Article
  2. Eukaryotic DNA polymerases: proposal for a revised nomenclature. Burgers PM, et al. J Biol Chem, 2001 Nov 23. PMID 11579108
  3. Drosophila suppressor of sable protein [Su(s)] promotes degradation of aberrant and transposon-derived RNAs. Kuan YS, et al. Mol Cell Biol, 2009 Oct. PMID 19687295, Free PMC Article
  4. Identification of ALK in Thinness. Orthofer M, et al. Cell, 2020 Jun 11. PMID 32442405
  5. TRF4 is involved in polyadenylation of snRNAs in Drosophila melanogaster. Nakamura R, et al. Mol Cell Biol, 2008 Nov. PMID 18765642, Free PMC Article

See all (29) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables poly(A) RNA polymerase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables poly(A) RNA polymerase activity IEA
Inferred from Electronic Annotation
more info
  
enables poly(A) RNA polymerase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in RNA 3'-end processing IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in nuclear polyadenylation-dependent ncRNA catabolic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in polyadenylation-dependent ncRNA catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of TRAMP complex IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleolus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleolus ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
topoisomerase related function 4-2
Names
CG17462-PA
CG17462-PB
Trf4-2-PA
Trf4-2-PB
NP_001262941.1
NP_651313.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    24925216..24927085
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_143056.3 → NP_651313.1  topoisomerase related function 4-2, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_651313.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9VC07
    Related
    FBpp0084094
    Conserved Domains (2) summary
    cd05402
    Location:52 → 161
    NT_PAP_TUTase; Nucleotidyltransferase (NT) domain of poly(A) polymerases and terminal uridylyl transferases
    pfam03828
    Location:221 → 280
    PAP_assoc; Cid1 family poly A polymerase

  2. NM_001276012.1 → NP_001262941.1  topoisomerase related function 4-2, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001262941.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9VC07
    Conserved Domains (2) summary
    cd05402
    Location:52 → 161
    NT_PAP_TUTase; Nucleotidyltransferase (NT) domain of poly(A) polymerases and terminal uridylyl transferases
    pfam03828
    Location:221 → 280
    PAP_assoc; Cid1 family poly A polymerase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VC07.1 Q9VC07

Gene LinkOut

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