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veli veli [ Drosophila melanogaster (fruit fly) ]

Gene ID: 43003, updated on 4-Jan-2025

Summary

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Official Symbol
veliprovided by FlyBase
Official Full Name
veliprovided by FlyBase
Primary source
FLYBASE:FBgn0039269
Locus tag
Dmel_CG7662
See related
AllianceGenome:FB:FBgn0039269
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG7662; d-Veli; D-veli; dLin-7; DLin-7; dLin7; DLin7; Dmel\CG7662; dVeli; Dveli; Flin-7; lin-7; Lin-7; lin7; Lin7; LIN7; Veli
Summary
Predicted to enable protein-macromolecule adaptor activity. Involved in border follicle cell migration and regulation of synaptic assembly at neuromuscular junction. Located in postsynaptic membrane. Part of subapical complex. Is expressed in several structures, including adult head; embryonic/larval neuromuscular junction; epithelium; gut section; and synaptic neuropil domain. Orthologous to several human genes including LIN7B (lin-7 homolog B, crumbs cell polarity complex component) and LIN7C (lin-7 homolog C, crumbs cell polarity complex component). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

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See veli in Genome Data Viewer
Location:
96B19-96B19; 3-86 cM
Exon count:
3
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (25064418..25065591, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (20890140..20891313, complement)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene staccato Neighboring gene Poly-glutamine tract binding protein 1 Neighboring gene Catalytic subunit 3B of the oligosaccharyltransferase complex Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. DLin-7 is required in postsynaptic lamina neurons to prevent light-induced photoreceptor degeneration in Drosophila. Soukup SF, et al. Curr Biol, 2013 Jul 22. PMID 23850283
  2. Cell type-specific recruitment of Drosophila Lin-7 to distinct MAGUK-based protein complexes defines novel roles for Sdt and Dlg-S97. Bachmann A, et al. J Cell Sci, 2004 Apr 15. PMID 15039455
  3. Drosophila Lin-7 is a component of the Crumbs complex in epithelia and photoreceptor cells and prevents light-induced retinal degeneration. Bachmann A, et al. Eur J Cell Biol, 2008 Mar. PMID 18177979
  4. Multiple domains of Stardust differentially mediate localisation of the Crumbs-Stardust complex during photoreceptor development in Drosophila. Bulgakova NA, et al. J Cell Sci, 2008 Jun 15. PMID 18495840
  5. Crumbs regulates polarity and prevents light-induced degeneration of the simple eyes of Drosophila, the ocelli. Mishra M, et al. Eur J Cell Biol, 2012 Sep. PMID 22608020

See all (55) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. At the photoreceptor synapse, DLin-7 acts as part of a conserved DLin-7/CASK/DlgS97 complex required to control the number of capitate projections and active zones, important specializations in the that are essential for proper neurotransmission.
    Title: DLin-7 is required in postsynaptic lamina neurons to prevent light-induced photoreceptor degeneration in Drosophila.
  2. DlgS97-Metro-DLin-7-type complexes control the proper organization of a synaptic junction; findings accentuate the importance of perisynaptic scaffold complexes for synaptic stabilization and organization
    Title: A perisynaptic ménage à trois between Dlg, DLin-7, and Metro controls proper organization of Drosophila synaptic junctions.
  3. study reports that Lin-7, a scaffolding protein with one Lin-2/Lin-7 domain & one PSD-95/Dlg/ZO-1 domain, is associated with the Crumbs complex in subapical region of embryonic & follicle epithelia & at the stalk membrane of adult photoreceptor cells
    Title: Drosophila Lin-7 is a component of the Crumbs complex in epithelia and photoreceptor cells and prevents light-induced retinal degeneration.
  4. recruitment of DLin-7 to MAGUK-based protein complexes is defined by cell-type specific mechanisms; DLin-7 acts downstream of Sdt in epithelia and downstream of Dlg at synapses [VELI is a synonym for Lin-7]
    Title: Cell type-specific recruitment of Drosophila Lin-7 to distinct MAGUK-based protein complexes defines novel roles for Sdt and Dlg-S97.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables protein-macromolecule adaptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in border follicle cell migration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in neurotransmitter secretion IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of synaptic assembly at neuromuscular junction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of synaptic assembly at neuromuscular junction IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in synaptic vesicle transport IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in basolateral plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cell-cell junction IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm HDA PubMed 
located_in postsynaptic membrane IDA
Inferred from Direct Assay
more info
 PubMed 
part_of subapical complex IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in synapse IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
veli
Names
CG7662-PA
CG7662-PC
veli-PA
veli-PC

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    25064418..25065591 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_143073.4 → NP_651330.1  veli, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_651330.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VBY7
    Related
    FBpp0084162
    Conserved Domains (2) summary
    cd00992
    Location:91 → 172
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam02828
    Location:14 → 66
    L27; L27 domain

  2. NM_170197.3 → NP_733076.2  veli, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_733076.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q6NL82, Q8IMT8
    Conserved Domains (2) summary
    cd00992
    Location:153 → 223
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam02828
    Location:14 → 66
    L27; L27 domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8IMT8 Q8IMT8
Q9VBY7 Q9VBY7

Gene LinkOut

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