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Cad96Ca Cadherin 96Ca [ Drosophila melanogaster (fruit fly) ]

Gene ID: 43026, updated on 9-Dec-2024

Summary

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Official Symbol
Cad96Caprovided by FlyBase
Official Full Name
Cadherin 96Caprovided by FlyBase
Primary source
FLYBASE:FBgn0022800
Locus tag
Dmel_CG10244
See related
AllianceGenome:FB:FBgn0022800
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
Cad 96Ca; cad96C; Cad96C; cad96Ca; CG10239; CG10244; CT28779; DCad96Ca; Dm Cad96Ca; Dmel\CG10244; DmHD-14; FGFR1-like; HD-14; stit
Summary
Enables protein tyrosine kinase activity. Involved in several processes, including negative regulation of cell size; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction; and positive regulation of wound healing. Located in apical part of cell. Is expressed in several structures, including adult tracheal system; embryonic anal pad; embryonic dorsal epidermis; embryonic epipharynx; and gut section. Human ortholog(s) of this gene implicated in arteriovenous malformation; multiple cutaneous and mucosal venous malformations; and renal Wilms' tumor. Orthologous to human TEK (TEK receptor tyrosine kinase). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See Cad96Ca in Genome Data Viewer
Location:
96C4-96C5; 3-87 cM
Exon count:
11
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (25197571..25208283, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (21023293..21034005, complement)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene lost boys Neighboring gene distal antenna Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene SAYSVFN motif domain containing 1 Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. PDZ-domain-binding sites are common among cadherins. Demontis F, et al. Dev Genes Evol, 2006 Nov. PMID 17021864
  2. Analysis of the Molecular Mechanisms of Reepithelialization in Drosophila Embryos. Matsubayashi Y, et al. Adv Wound Care (New Rochelle), 2016 Jun 1. PMID 27274434, Free PMC Article
  3. Src kinases and ERK activate distinct responses to Stitcher receptor tyrosine kinase signaling during wound healing in Drosophila. Tsarouhas V, et al. J Cell Sci, 2014 Apr 15. PMID 24522188
  4. The tyrosine kinase Stitcher activates Grainy head and epidermal wound healing in Drosophila. Wang S, et al. Nat Cell Biol, 2009 Jul. PMID 19525935
  5. Two-tiered control of epithelial growth and autophagy by the insulin receptor and the ret-like receptor, stitcher. O'Farrell F, et al. PLoS Biol, 2013 Jul. PMID 23935447, Free PMC Article

See all (62) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The Ret-like receptor tyrosine kinase Stitcher regulates both re-epithelialization and transcriptional activation by Grainy head to induce restoration of the extracellular barrier.
    Title: Src kinases and ERK activate distinct responses to Stitcher receptor tyrosine kinase signaling during wound healing in Drosophila.
  2. The combined activities of Stit and InR in ectodermal epithelial tissues provide an RTK-mediated, two-tiered reaction threshold to varying nutritional conditions that promote epithelial organ growth even at low levels of InR signaling.
    Title: Two-tiered control of epithelial growth and autophagy by the insulin receptor and the ret-like receptor, stitcher.
  3. Daya identified stitcher (stit, CG10244), a new Grh target and show that Stit activation upon wounding coordinates cytoskeletal rearrangements and the level of Grh-mediated transcriptional wound responses.
    Title: The tyrosine kinase Stitcher activates Grainy head and epidermal wound healing in Drosophila.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein tyrosine kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein tyrosine kinase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables protein tyrosine kinase activity NAS
Non-traceable Author Statement
more info
 PubMed 
enables transmembrane receptor protein tyrosine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in Golgi organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in cell surface receptor protein tyrosine kinase signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in homophilic cell adhesion via plasma membrane adhesion molecules IEA
Inferred from Electronic Annotation
more info
  
involved_in multicellular organism development IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of cell size IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of wound healing IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in protein phosphorylation NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in wound healing IEP
Inferred from Expression Pattern
more info
 PubMed 
Component Evidence Code Pubs
located_in apical part of cell IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
part_of receptor complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
cadherin 96Ca
Names
CG10244-PA
Cad96Ca-PA
stitcher
NP_651349.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    25197571..25208283 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_143092.3 → NP_651349.1  cadherin 96Ca [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_651349.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O18368, Q8SZC9, Q9VBW2, Q9VBW3
    Related
    FBpp0084248
    Conserved Domains (3) summary
    cd11304
    Location:65 → 164
    Cadherin_repeat; Cadherin tandem repeat domain
    smart00221
    Location:470 → 741
    STYKc; Protein kinase; unclassified specificity
    cd00192
    Location:474 → 742
    PTKc; Catalytic domain of Protein Tyrosine Kinases
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VBW3.2 Q9VBW3

Gene LinkOut

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