bam bag of marbles [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: bamprovided by FlyBase
Official Full Name: bag of marblesprovided by FlyBase
Primary source: FLYBASE:FBgn0000158
Locus tag: Dmel_CG10422
See related: AllianceGenome:FB:FBgn0000158
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: alpha; Bam; BAM; Bam-C; BamC; BamF; CG10422; Dmel\CG10422; fs(3)neo61; ham
Summary: Enables mRNA 3'-UTR binding activity; mRNA regulatory element binding translation repressor activity; and ubiquitin binding activity. Involved in several processes, including germ cell development; regulation of protein metabolic process; and regulation of signal transduction. Located in fusome and spectrosome. Is expressed in several structures, including centripetal follicle cell; germarium region 1; germarium region 2; germline cell; and gonad. Used to study germ cell cancer. [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: all
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Genomic context

Location:: 96C7-96C8; 3-87 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (25243039..25245109, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3R	NT_033777.2 (21068761..21070779, complement)

Chromosome 3R - NT_033777.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Wolbachia infection at least partially rescues the fertility and ovary defects of several new Drosophila melanogaster bag of marbles protein-coding mutants.
Title: Wolbachia infection at least partially rescues the fertility and ovary defects of several new Drosophila melanogaster bag of marbles protein-coding mutants.
A conserved role of bam in maintaining metabolic homeostasis via regulating intestinal microbiota in Drosophila.
Title: A conserved role of bam in maintaining metabolic homeostasis via regulating intestinal microbiota in Drosophila.
A transitory signaling center controls timing of primordial germ cell differentiation.
Title: A transitory signaling center controls timing of primordial germ cell differentiation.
Findings identify Bag-of-marbles (Bam) as a new pumilio (Pum) cofactor in repression of Mothers against dpp (mad) 3' UTR in Schneider's 2 cells (S2 cells).
Title: The target specificity of the RNA binding protein Pumilio is determined by distinct co-factors.
oalescence-mediated enzymatic activity of Otu is positively regulated by its bound RNAs and co-partner Bam. Further genetic analysis reveals that the Otu/Bam deubiquitinase complex and dTraf6 constitute a feedback loop to maintain intestinal immune homeostasis during aging, thereby controlling longevity.
Title: LC Domain-Mediated Coalescence Is Essential for Otu Enzymatic Activity to Extend Drosophila Lifespan.
The somatic EGFR-ERK activity appeared to regulate the termination of Bam expression in the germline and promote subsequent differentiation to the spermatocyte stage.
Title: Somatic ERK activation during transit amplification is essential for maintaining the synchrony of germline divisions in Drosophila testis.
The germline linker histone dBigH1 and the translational regulator Bam form a repressor loop essential for male germ stem cell differentiation.
Title: The Germline Linker Histone dBigH1 and the Translational Regulator Bam Form a Repressor Loop Essential for Male Germ Stem Cell Differentiation.
Bam regulates the expression of its mRNA targets by recruiting the CCR4-NOT complex through interaction with CAF40.
Title: Drosophila Bag-of-marbles directly interacts with the CAF40 subunit of the CCR4-NOT complex to elicit repression of mRNA targets.
Adaptive evolution of bam has been driven at least in part by the long-term interactions between Drosophila species and Wolbachia.
Title: The Drosophila bag of marbles Gene Interacts Genetically with Wolbachia and Shows Female-Specific Effects of Divergence.
Our in vivo and in vitro evidence illustrate that Tut acts with Bam, Bgcn to accurately coordinate proliferation and differentiation in Drosophila germline stem cell lineage.
Title: Three RNA binding proteins form a complex to promote differentiation of germline stem cell lineage in Drosophila.

Submit: New GeneRIF Correction See all GeneRIFs (25)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables mRNA 3'-UTR binding	IDA Inferred from Direct Assay more info	PubMed
enables mRNA regulatory element binding translation repressor activity	IDA Inferred from Direct Assay more info	PubMed
enables ubiquitin binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in cell competition in a multicellular organism	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cystoblast division	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in female germ-line stem cell asymmetric division	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in fusome organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in gamete generation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in germ-line stem cell division	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in germ-line stem cell population maintenance	IDA Inferred from Direct Assay more info	PubMed
involved_in germ-line stem cell population maintenance	IGI Inferred from Genetic Interaction more info	PubMed
involved_in germ-line stem cell population maintenance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in germarium-derived female germ-line cyst formation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in male germline stem cell symmetric division	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of peptidoglycan recognition protein signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of translation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in oogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of protein K63-linked deubiquitination	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of protein deubiquitination	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of smoothened signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of stem cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in spermatogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in spermatogonial cell division	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in fusome	IDA Inferred from Direct Assay more info	PubMed
located_in spectrosome	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: bag of marbles

Names: CG10422-PA; bag of marble; bag-of-marbles; bam-PA; transcript alpha

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033777.3 Reference assembly

Range

25243039..25245109 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_057452.4 → NP_476800.1 bag of marbles [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_476800.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P22745, Q2PNQ8, Q2PNQ9, Q2PNR5, Q2PNR8, Q2PNR9, Q2PNS3, Q2PNS6, Q2PNS8, Q2PNT1, Q8MRX8, Q9VBV0

UniProtKB/TrEMBL

A1YJS5, B5RIV8

Related

FBpp0084243

Nucleotide		Protein
Heading	Accession and Version	Protein

Protein Accession	Links
Protein Accession	GenPept Link	UniProtKB Link
A1YJR7		A1YJR7
A1YJR9		A1YJR9
A1YJS0		A1YJS0
A1YJS3		A1YJS3
A1YJS5		A1YJS5
A1YJS7		A1YJS7
A1YJT1		A1YJT1
A1YJT3		A1YJT3
P22745.3		P22745