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Npl4 Nuclear protein localization 4 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 43091, updated on 4-Jan-2025

Summary

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Official Symbol
Npl4provided by FlyBase
Official Full Name
Nuclear protein localization 4provided by FlyBase
Primary source
FLYBASE:FBgn0039348
Locus tag
Dmel_CG4673
See related
AllianceGenome:FB:FBgn0039348
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG4673; Dmel\CG4673; dNp14; dNpl4; dNPLOC4; npl4; NPL4
Summary
Enables K11-linked polyubiquitin modification-dependent protein binding activity. Involved in cellular response to virus; negative regulation of smoothened signaling pathway; and ubiquitin-dependent protein catabolic process. Located in cytosol and nucleoplasm. Is expressed in several structures, including adult brain cell body rind; adult gnathal ganglion; adult head; adult heart; and synaptic neuropil domain. Used to study neurodegenerative disease. Orthologous to human NPLOC4 (NPL4 homolog, ubiquitin recognition factor). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

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See Npl4 in Genome Data Viewer
Location:
96E4-96E6; 3-88 cM
Exon count:
9
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (25611013..25624662, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (21436735..21450384, complement)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene musashi Neighboring gene long non-coding RNA:CR45910 Neighboring gene mir-1000 stem loop Neighboring gene yellow-emperor Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Succinic semialdehyde dehydrogenase Neighboring gene jing interacting gene regulatory 1 Neighboring gene mir-92a stem loop

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Roles for the VCP co-factors Npl4 and Ufd1 in neuronal function in Drosophila melanogaster. Byrne DJ, et al. J Genet Genomics, 2017 Oct 20. PMID 29037990, Free PMC Article
  2. Genome-wide RNAi screen identifies SEC61A and VCP as conserved regulators of Sindbis virus entry. Panda D, et al. Cell Rep, 2013 Dec 26. PMID 24332855, Free PMC Article
  3. RNA interference of valosin-containing protein (VCP/p97) reveals multiple cellular roles linked to ubiquitin/proteasome-dependent proteolysis. Wójcik C, et al. J Cell Sci, 2004 Jan 15. PMID 14657277
  4. Segmental duplication, microinversion, and gene loss associated with a complex inversion breakpoint region in Drosophila. Calvete O, et al. Mol Biol Evol, 2012 Jul. PMID 22328714, Free PMC Article
  5. Wld S requires Nmnat1 enzymatic activity and N16-VCP interactions to suppress Wallerian degeneration. Avery MA, et al. J Cell Biol, 2009 Feb 23. PMID 19237597, Free PMC Article

See all (56) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. differing neuronal functions of Npl4 and Ufd1 in vivo
    Title: Roles for the VCP co-factors Npl4 and Ufd1 in neuronal function in Drosophila melanogaster.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables K11-linked polyubiquitin modification-dependent protein binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables ubiquitin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ubiquitin protein ligase binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in cellular response to virus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of smoothened signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in ubiquitin-dependent protein catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in ubiquitin-dependent protein catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytosol HDA PubMed 
located_in nucleoplasm HDA PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
nuclear protein localization 4
Names
CG4673-PA
CG4673-PB
CG4673-PD
Npl4 ortholog
Npl4-PA
Npl4-PB
Npl4-PD

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    25611013..25624662 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_170231.3 → NP_733110.2  nuclear protein localization 4, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_733110.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9VBP9
    Conserved Domains (6) summary
    smart00547
    Location:599 → 623
    ZnF_RBZ; Zinc finger domain
    COG5100
    Location:6 → 527
    NPL4; Nuclear pore protein [Nuclear structure]
    sd00029
    Location:601 → 620
    zf-RanBP2; RanBP2-type Zn finger [structural motif]
    pfam05020
    Location:113 → 251
    zf-NPL4; NPL4 family, putative zinc binding region
    pfam05021
    Location:254 → 565
    NPL4; NPL4 family
    pfam11543
    Location:5 → 78
    UN_NPL4; Nuclear pore localization protein NPL4

  2. NM_001170260.2 → NP_001163731.1  nuclear protein localization 4, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001163731.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9VBP9
    Conserved Domains (6) summary
    smart00547
    Location:599 → 623
    ZnF_RBZ; Zinc finger domain
    COG5100
    Location:6 → 527
    NPL4; Nuclear pore protein [Nuclear structure]
    sd00029
    Location:601 → 620
    zf-RanBP2; RanBP2-type Zn finger [structural motif]
    pfam05020
    Location:113 → 251
    zf-NPL4; NPL4 family, putative zinc binding region
    pfam05021
    Location:254 → 565
    NPL4; NPL4 family
    pfam11543
    Location:5 → 78
    UN_NPL4; Nuclear pore localization protein NPL4

  3. NM_143150.4 → NP_651407.3  nuclear protein localization 4, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_651407.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    C9QPJ1, E1JIX5, H8F4R9, Q8IMS6, Q95U63, Q9VBP9
    Conserved Domains (6) summary
    smart00547
    Location:627 → 651
    ZnF_RBZ; Zinc finger domain
    COG5100
    Location:35 → 555
    NPL4; Nuclear pore protein [Nuclear structure]
    sd00029
    Location:629 → 648
    zf-RanBP2; RanBP2-type Zn finger [structural motif]
    pfam05020
    Location:141 → 279
    zf-NPL4; NPL4 family, putative zinc binding region
    pfam05021
    Location:282 → 593
    NPL4; NPL4 family
    pfam11543
    Location:33 → 106
    UN_NPL4; Nuclear pore localization protein NPL4
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VBP9.3 Q9VBP9

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