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CLS Cardiolipin synthase [ Drosophila melanogaster (fruit fly) ]

Gene ID: 43104, updated on 4-Jan-2025

Summary

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Official Symbol
CLSprovided by FlyBase
Official Full Name
Cardiolipin synthaseprovided by FlyBase
Primary source
FLYBASE:FBgn0039360
Locus tag
Dmel_CG4774
See related
AllianceGenome:FB:FBgn0039360
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG4774; dCLS; Dmel\CG4774
Summary
Enables cardiolipin synthase (CMP-forming). Predicted to be involved in cardiolipin biosynthetic process. Predicted to be located in mitochondrial inner membrane. Predicted to be active in mitochondrion. Is expressed in adult head. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency 57. Orthologous to human CRLS1 (cardiolipin synthase 1). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
all
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Genomic context

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See CLS in Genome Data Viewer
Location:
96E10-96E10; 3-88 cM
Exon count:
5
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (25685236..25687370, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (21510958..21513092, complement)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Isocitrate dehydrogenase (NAD(+)) 3 non-catalytic subunit gamma Neighboring gene Ribosomal protein L27 Neighboring gene Lipophorin receptor 2 Neighboring gene long non-coding RNA:CR46102 Neighboring gene Lipophorin receptor 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Depletion of cardiac cardiolipin synthase alters systolic and diastolic function. Smeir E, et al. iScience, 2021 Nov 19. PMID 34805785, Free PMC Article
  2. Cardiolipin remodeling enables protein crowding in the inner mitochondrial membrane. Xu Y, et al. EMBO J, 2021 Dec 1. PMID 34661298, Free PMC Article
  3. Tafazzins from Drosophila and mammalian cells assemble in large protein complexes with a short half-life. Xu Y, et al. Mitochondrion, 2015 Mar. PMID 25598000, Free PMC Article
  4. Cardiolipin affects the supramolecular organization of ATP synthase in mitochondria. Acehan D, et al. Biophys J, 2011 May 4. PMID 21539786, Free PMC Article
  5. Ceramide phosphoethanolamine biosynthesis in Drosophila is mediated by a unique ethanolamine phosphotransferase in the Golgi lumen. Vacaru AM, et al. J Biol Chem, 2013 Apr 19. PMID 23449981, Free PMC Article

See all (30) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables cardiolipin synthase (CMP-forming) IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cardiolipin synthase (CMP-forming) IDA
Inferred from Direct Assay
more info
 PubMed 
enables phosphotransferase activity, for other substituted phosphate groups IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cardiolipin biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of mitochondrial membrane organization IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in phospholipid biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrial inner membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
cardiolipin synthase
Names
CG4774-PA
CG4774-PB
CG4774-PC
CG4774-PD
CLS-PA
CLS-PB
CLS-PC
CLS-PD
cardiolipin
NP_001262969.1
NP_651418.1
NP_733116.1
NP_733117.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    25685236..25687370 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001276040.1 → NP_001262969.1  cardiolipin synthase, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001262969.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A4V3F1, Q8MZC4, Q9VBN4
    UniProtKB/TrEMBL
    A0A0B4KHW4
    Conserved Domains (1) summary
    COG0558
    Location:125 → 316
    PgsA; Phosphatidylglycerophosphate synthase [Lipid transport and metabolism]

  2. NM_170237.2 → NP_733116.1  cardiolipin synthase, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_733116.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A4V3F1, Q8MZC4, Q9VBN4
    UniProtKB/TrEMBL
    A0A0B4KHW4
    Related
    FBpp0084303
    Conserved Domains (1) summary
    COG0558
    Location:125 → 316
    PgsA; Phosphatidylglycerophosphate synthase [Lipid transport and metabolism]

  3. NM_143161.2 → NP_651418.1  cardiolipin synthase, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_651418.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A4V3F1, Q8MZC4, Q9VBN4
    UniProtKB/TrEMBL
    A0A0B4KHW4
    Related
    FBpp0084304
    Conserved Domains (1) summary
    COG0558
    Location:125 → 316
    PgsA; Phosphatidylglycerophosphate synthase [Lipid transport and metabolism]

  4. NM_170238.2 → NP_733117.1  cardiolipin synthase, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_733117.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A4V3F1, Q8MZC4, Q9VBN4
    UniProtKB/TrEMBL
    A0A0B4KHW4
    Related
    FBpp0084305
    Conserved Domains (1) summary
    COG0558
    Location:125 → 316
    PgsA; Phosphatidylglycerophosphate synthase [Lipid transport and metabolism]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A0B4KHW4 A0A0B4KHW4
Q8MZC4.1 Q8MZC4

Gene LinkOut

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