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E(spl)mgamma-HLH Enhancer of split mgamma, helix-loop-helix [ Drosophila melanogaster (fruit fly) ]

Gene ID: 43151, updated on 9-Dec-2024

Summary

Official Symbol
E(spl)mgamma-HLHprovided by FlyBase
Official Full Name
Enhancer of split mgamma, helix-loop-helixprovided by FlyBase
Primary source
FLYBASE:FBgn0002735
Locus tag
Dmel_CG8333
See related
AllianceGenome:FB:FBgn0002735
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
anon-EST:Liang-1.49; bHLHb34; CG8333; clone 1.49; Dm-mB; Dmel\CG8333; E(Spl) HLH-m gamma; E(spl) m gamma; E(spl) mg; E(spl) mgamma; E(spl)-mgamma; E(spl)gamma; E(spl)m-gamma; E(spl)mB; e(spl)mgamma; E(spl)mgamma; E(spl)Mgamma; EE(spl)mgamma-HLH; Enhancer of split mgamma; gamma; HLH-mgamma; HLHmB; HlHmg; HLHmgamma; HLHMgamma; mB; mg; mgamma; Mgamma
Summary
Enables DNA-binding transcription factor activity; DNA-binding transcription factor binding activity; and cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including neuronal stem cell population maintenance; positive regulation of neuroblast proliferation; and wing disc dorsal/ventral pattern formation. Located in nucleus. Is expressed in several structures, including chaeta; embryonic segment; germ layer; head epidermis primordium; and larval optic anlage. Used to study central nervous system cancer. Orthologous to human HES2 (hes family bHLH transcription factor 2). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

See E(spl)mgamma-HLH in Genome Data Viewer
Location:
96F9-96F9; 3-89 cM
Exon count:
1
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (25999851..26000761)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (21825573..21826483)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Enhancer of split mdelta, helix-loop-helix Neighboring gene long non-coding RNA:CR45037 Neighboring gene long non-coding RNA:CR45038

Genomic regions, transcripts, and products

Bibliography

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by FlyBase

Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus IMP
Inferred from Mutant Phenotype
more info
PubMed 

General protein information

Preferred Names
enhancer of split mgamma, helix-loop-helix
Names
CG8333-PA
E(spl) region transcript g
E(spl) region transcript mgamma
E(spl)mgamma-HLH-PA
enhancer of split
enhancer of split mgamma
enhancer of split region transcript HLHmB
mgamma
split locus enhancer protein mB

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    25999851..26000761
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_079780.3NP_524504.2  enhancer of split mgamma, helix-loop-helix [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_524504.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q01070, Q01898, Q5S4K4
    Related
    FBpp0084329
    Conserved Domains (2) summary
    smart00511
    Location:91135
    ORANGE; Orange domain
    cd00083
    Location:1577
    HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...