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E(spl)mbeta-HLH - Enhancer of split mbeta, helix-loop-helix

Enables DNA-binding transcription repressor activity, RNA polymerase II-specific and sequence-specific double-stranded DNA binding activity. Involved in negative regulation of transcription by RNA polymerase II and positive regulation of neuroblast proliferation. Acts upstream of with a negative effect on chaeta development. Located in nucleus. Is expressed in several structures, including gut section; head epidermis primordium; imaginal disc; organism subdivision; and somatic trunk mesoderm derivative. Orthologous to human HES2 (hes family bHLH transcription factor 2). [provided by Alliance of Genome Resources, Dec 2024]

Genes similar to E(spl)mbeta-HLH

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Species Gene Architecture aa