U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

E(spl)malpha-BFM Enhancer of split malpha, Bearded family member [ Drosophila melanogaster (fruit fly) ]

Gene ID: 43153, updated on 9-Dec-2024

Summary

Go to the top of the page Help
Official Symbol
E(spl)malpha-BFMprovided by FlyBase
Official Full Name
Enhancer of split malpha, Bearded family memberprovided by FlyBase
Primary source
FLYBASE:FBgn0002732
Locus tag
Dmel_CG8337
See related
AllianceGenome:FB:FBgn0002732
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG8337; DmelCG8337; Dmel\CG8337; E(spl) malpha; E(spl)ma; E(spl)malpha; E(spl)mmalpha; HLHmalpha; malpha
Summary
Enables ubiquitin protein ligase binding activity. Involved in cell fate specification; negative regulation of Notch signaling pathway; and sensory organ development. Is expressed in several structures, including anterior-posterior compartment boundary of the wing disc; epithelium; eye disc posterior to the morphogenetic furrow; imaginal disc; and organism subdivision. [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See E(spl)malpha-BFM in Genome Data Viewer
Location:
96F10-96F10; 3-89 cM
Exon count:
1
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (26010893..26011568)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (21836615..21837290)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Enhancer of split mbeta, helix-loop-helix Neighboring gene long non-coding RNA:CR45039 Neighboring gene long non-coding RNA:CR45040 Neighboring gene Kazal-type protease inhibitor m1 Neighboring gene Enhancer of split m2, Bearded family member

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Role of architecture in the function and specificity of two Notch-regulated transcriptional enhancer modules. Liu F, et al. PLoS Genet, 2012 Jul. PMID 22792075, Free PMC Article
  2. New Drosophila transgenic reporters: insulated P-element vectors expressing fast-maturing RFP. Barolo S, et al. Biotechniques, 2004 Mar. PMID 15038159
  3. A Drosophila Su(H) model of Adams-Oliver Syndrome reveals cofactor titration as a mechanism underlying developmental defects. Gagliani EK, et al. PLoS Genet, 2022 Aug. PMID 35951645, Free PMC Article
  4. Lateral inhibition: Two modes of non-autonomous negative autoregulation by neuralized. Miller SW, et al. PLoS Genet, 2018 Jul. PMID 30028887, Free PMC Article
  5. Spatial regulation of contractility by Neuralized and Bearded during furrow invagination in Drosophila. Perez-Mockus G, et al. Nat Commun, 2017 Nov 17. PMID 29150614, Free PMC Article

See all (102) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables ubiquitin protein ligase binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in Notch signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in cell fate specification IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of Notch signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in sensory organ development IEA
Inferred from Electronic Annotation
more info
  
involved_in sensory organ development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  

General protein information

Go to the top of the page Help
Preferred Names
enhancer of split malpha, bearded family member
Names
CG8337-PA
E(spl) region transcript malpha
E(spl)malpha
E(spl)malpha-BFM-PA

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    26010893..26011568
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_079782.3 → NP_524506.1  enhancer of split malpha, bearded family member [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_524506.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A8E6W7, O97178, Q56MK8, Q56MK9, Q56ML2, Q56ML4, Q56MM3, Q56MM6, Q56MN5, Q56MP7, Q56MQ1, Q56MQ4, Q56MT0, Q5S4K2
    UniProtKB/TrEMBL
    A0A1B2AKK5
    Related
    FBpp0084330
    Conserved Domains (1) summary
    pfam15952
    Location:1 → 138
    ESM4; Enhancer of split M4 family
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O97178.1 O97178

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Other Literature Sources
Chemical Information
Molecular Biology Databases
Research Materials
Tools