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E(spl)m6-BFM Enhancer of split m6, Bearded family member [ Drosophila melanogaster (fruit fly) ]

Gene ID: 43159, updated on 4-Jan-2025

Summary

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Official Symbol
E(spl)m6-BFMprovided by FlyBase
Official Full Name
Enhancer of split m6, Bearded family memberprovided by FlyBase
Primary source
FLYBASE:FBgn0002632
Locus tag
Dmel_CG8354
See related
AllianceGenome:FB:FBgn0002632
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG8354; DmelCG8354; Dmel\CG8354; E(spl)-m6; E(spl)m6; E(spl)M6; HLHm6; m6; M6
Summary
Enables ubiquitin protein ligase binding activity. Involved in cell fate specification; negative regulation of Notch signaling pathway; and sensory organ development. Is expressed in several structures, including embryonic/larval midgut; ganglia; myoblast; presumptive embryonic/larval system; and section of wing margin. [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

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See E(spl)m6-BFM in Genome Data Viewer
Location:
96F10-96F10; 3-89 cM
Exon count:
1
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (26032911..26034047)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (21858633..21859769)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Enhancer of split m4, Bearded family member Neighboring gene Enhancer of split m5, helix-loop-helix Neighboring gene Enhancer of split m7, helix-loop-helix Neighboring gene Enhancer of split m8, helix-loop-helix

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Dual-Color Live Imaging of Adult Muscle Stem Cells in the Embryonic Tissues of Drosophila melanogaster. Zmojdzian M, et al. Bio Protoc, 2023 Feb 5. PMID 36816994, Free PMC Article
  2. Matrix metalloproteinases: Master regulators of tissue morphogenesis. Sreesada P, et al. Gene, 2025 Jan 15. PMID 39393432
  3. Two genetically and molecularly distinct functions involved in early neurogenesis reside within the Enhancer of split locus of Drosophila melanogaster. Delidakis C, et al. Genetics, 1991 Nov. PMID 1752423, Free PMC Article
  4. Closely related transcripts encoded by the neurogenic gene complex enhancer of split of Drosophila melanogaster. Klämbt C, et al. EMBO J, 1989 Jan. PMID 2540957, Free PMC Article
  5. A forward genetic screen in Drosophila implicates insulin signaling in age-related locomotor impairment. Jones MA, et al. Exp Gerontol, 2009 Aug. PMID 19481596, Free PMC Article

See all (89) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables ubiquitin protein ligase binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell fate specification IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of Notch signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in sensory organ development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  

General protein information

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Preferred Names
enhancer of split m6, bearded family member
Names
CG8354-PA
E(spl) region transcript m6
E(spl)m6-BFM-PA
enhancer of split m6
enhancer of split region transcript m6

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    26032911..26034047
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_079788.3 → NP_524512.2  enhancer of split m6, bearded family member [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_524512.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    C9QP91, C9QPH4, O97179, Q5S4C4, Q5S4H2, Q5S4J6, Q9VBI7
    Related
    FBpp0084333
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O97179.2 O97179

Gene LinkOut

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