E(spl)m7-HLH - Enhancer of split m7, helix-loop-helix
Enables several functions, including DNA-binding transcription factor binding activity; DNA-binding transcription repressor activity, RNA polymerase II-specific; and transcription corepressor binding activity. Involved in negative regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in several structures, including amnioserosa anlage; embryonic segment; epidermis; germ layer; and head epidermis primordium. Orthologous to human HES2 (hes family bHLH transcription factor 2). [provided by Alliance of Genome Resources, Dec 2024]
NCBI Orthologs
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Protein alignment
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