nr4a1 nuclear receptor subfamily 4, group A, member 1 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: nr4a1provided by ZNC
Official Full Name: nuclear receptor subfamily 4, group A, member 1provided by ZNC
Primary source: ZFIN:ZDB-GENE-040704-11
See related: Ensembl:ENSDARG00000000796 AllianceGenome:ZFIN:ZDB-GENE-040704-11
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: NUR77; zgc:92434
Summary: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and nuclear glucocorticoid receptor binding activity. Acts upstream of or within regulation of glucose metabolic process. Predicted to be located in cytosol. Predicted to be part of transcription regulator complex. Predicted to be active in nucleus. Is expressed in axis; myotome; nervous system; and pectoral fin. Orthologous to human NR4A1 (nuclear receptor subfamily 4 group A member 1). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 23

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	23	NC_007134.7 (32151333..32157843, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	23	NC_007134.6 (32224800..32231403, complement)

Chromosome 23 - NC_007134.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Orphan nuclear receptor Nur77 promotes acute kidney injury and renal epithelial apoptosis in mice.
Title: Orphan nuclear receptor Nur77 promotes acute kidney injury and renal epithelial apoptosis.

Submit: New GeneRIF Correction

General gene information

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Markers

fc19f03.x1 (e-PCR)
- UniSTS:192937

fc19f03.x1 (e-PCR)
- UniSTS:192938

fc19f08.y1 (e-PCR)
- UniSTS:192942

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables nuclear glucocorticoid receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables nuclear receptor activity	IEA Inferred from Electronic Annotation more info
enables sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cellular response to corticotropin-releasing hormone stimulus	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within inflammatory response	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of glucose metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in cytosol	IEA Inferred from Electronic Annotation more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
part_of transcription regulator complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: nuclear receptor subfamily 4immunitygroup A member 1

Names: NGFIB; neural orphan nuclear receptor NUR77

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001002173.1 → NP_001002173.1 nuclear receptor subfamily 4immunitygroup A member 1

See identical proteins and their annotated locations for NP_001002173.1

Status: PROVISIONAL

Source sequence(s)

BC074092

UniProtKB/TrEMBL

A0A0R4IZL4, F6PCB9, Q6GMG3

Related

ENSDARP00000001911.9, ENSDART00000000876.11

Conserved Domains (2) summary

cd07348
Location:337 → 574

NR_LBD_NGFI-B; The ligand binding domain of Nurr1, a member of conserved family of nuclear receptors

cd06969
Location:237 → 311

NR_DBD_NGFI-B; DNA-binding domain of the orphan nuclear receptor, nerve growth factor-induced-B