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cpa4 carboxypeptidase A4 [ Danio rerio (zebrafish) ]

Gene ID: 431764, updated on 4-Jan-2025

Summary

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Official Symbol
cpa4provided by ZNC
Official Full Name
carboxypeptidase A4provided by ZNC
Primary source
ZFIN:ZDB-GENE-040704-61
See related
Ensembl:ENSDARG00000043722 AllianceGenome:ZFIN:ZDB-GENE-040704-61
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
zgc:91794; wu:fb66g10
Summary
Predicted to enable metallocarboxypeptidase activity. Predicted to be involved in proteolysis. Predicted to be active in extracellular space. Is expressed in pancreas and somite. Orthologous to several human genes including CPA2 (carboxypeptidase A2). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
all
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Genomic context

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See cpa4 in Genome Data Viewer
Location:
chromosome: 25
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 25 NC_007136.7 (16582172..16589461, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 25 NC_007136.6 (16485772..16493061, complement)

Chromosome 25 - NC_007136.7Genomic Context describing neighboring genes Neighboring gene suppressor APC domain-containing protein 1-like Neighboring gene structural maintenance of chromosomes 1B Neighboring gene carboxypeptidase A2 (pancreatic) Neighboring gene ATPase H+ transporting V1 subunit E1a

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Analysis of the mast cell expressed carboxypeptidase A3 and its structural and evolutionary relationship to other vertebrate carboxypeptidases. Akula S, et al. Dev Comp Immunol, 2022 Feb. PMID 34619175
  2. Carboxypeptidase A6 in zebrafish development and implications for VIth cranial nerve pathfinding. Lyons PJ, et al. PLoS One, 2010 Sep 24. PMID 20885977, Free PMC Article
  3. Knockout of zebrafish colony-stimulating factor 1 receptor by CRISPR/Cas9 affects metabolism and locomotion capacity. Meng H, et al. Biochem Biophys Res Commun, 2021 Apr 30. PMID 33725575
  4. Knockdown of Carboxypeptidase A6 in Zebrafish Larvae Reduces Response to Seizure-Inducing Drugs and Causes Changes in the Level of mRNAs Encoding Signaling Molecules. Lopes MW, et al. PLoS One, 2016. PMID 27050163, Free PMC Article
  5. LRH-1 senses signaling from phosphatidylcholine to regulate the expansion growth of digestive organs via synergy with Wnt/β-catenin signaling in zebrafish. Zhai G, et al. J Genet Genomics, 2017 Jun 20. PMID 28642062

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables carboxypeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables metallocarboxypeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metallocarboxypeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables metallopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables peptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in proteolysis IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within proteolysis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
carboxypeptidase A4
NP_001002217.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001002217.1 → NP_001002217.1  carboxypeptidase A4 precursor

    See identical proteins and their annotated locations for NP_001002217.1

    Status: PROVISIONAL

    Source sequence(s)
    BC074071
    UniProtKB/TrEMBL
    Q6GMH9
    Related
    ENSDARP00000064203.3, ENSDART00000064204.4
    Conserved Domains (2) summary
    cd03870
    Location:115 → 415
    M14_CPA; Peptidase M14 carboxypeptidase subfamily A/B-like; Carboxypeptidase A subgroup
    pfam02244
    Location:27 → 97
    Propep_M14; Carboxypeptidase activation peptide

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007136.7 Reference GRCz11 Primary Assembly

    Range
    16582172..16589461 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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