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Ald1 Aldolase 1 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 43183, updated on 4-Jan-2025

Summary

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Official Symbol
Ald1provided by FlyBase
Official Full Name
Aldolase 1provided by FlyBase
Primary source
FLYBASE:FBgn0000064
Locus tag
Dmel_CG6058
See related
AllianceGenome:FB:FBgn0000064
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
ald; Ald; ALD; ALDOA; Aldolase; BcDNA:LP07735; CG6058; dALDOA; Dmel\CG6058; FBA; T12; T4; T6; T7
Summary
Enables fructose-1-phosphate aldolase activity and fructose-bisphosphate aldolase activity. Involved in several processes, including canonical glycolysis; fructose 1,6-bisphosphate metabolic process; and glucose homeostasis. Located in M band and Z disc. Is expressed in several structures, including adult brain cell body rind; adult head; adult heart; calyx of adult mushroom body; and embryonic/larval CNS perineurial glial cell. Human ortholog(s) of this gene implicated in autoimmune disease of the nervous system; hereditary fructose intolerance syndrome; and type 2 diabetes mellitus. Orthologous to several human genes including ALDOC (aldolase, fructose-bisphosphate C). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
all
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Genomic context

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See Ald1 in Genome Data Viewer
Location:
97A6-97A6; 3-90 cM
Exon count:
8
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (26254069..26261591, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (22079791..22087313, complement)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR44320 Neighboring gene long non-coding RNA:CR46061 Neighboring gene long non-coding RNA:CR46062 Neighboring gene uncharacterized protein Neighboring gene antisense RNA:CR44321 Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR42765 Neighboring gene oskyddad

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Hybridisation of aldolase from Drosophila, blocked at the active site, with native C aldolase from calf brain. Brenner-Holzach O, et al. Eur J Biochem, 1972 Dec 18. PMID 4631006
  2. Introns resolve the conflict between base order-dependent stem-loop potential and the encoding of RNA or protein: further evidence from overlapping genes. Barrette IH, et al. Gene, 2001 May 30. PMID 11404015
  3. Drosophila melanogaster aldolase: characterization of the isozymes alpha, beta, and gamma generated from a single gene. Zhang R, et al. J Biochem, 1995 Jul. PMID 8537310
  4. Saccharomyces cerevisiae phosphoglucose isomerase and fructose bisphosphate aldolase can be replaced functionally by the corresponding enzymes of Escherichia coli and Drosophila melanogaster. Boles E, et al. Curr Genet, 1993 Mar. PMID 8435847
  5. Analysis of the in vitro translation product of a novel-type Drosophila melanogaster aldolase mRNA in which two carboxyl-terminal exons remain unspliced. Sugimoto Y, et al. Arch Biochem Biophys, 1995 Nov 10. PMID 7487099

See all (146) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. This study demonistrated that a mutation in Drosophila Aldolase causes temperature-sensitive paralysis, shortened lifespan, and neurodegeneration.
    Title: A mutation in Drosophila Aldolase causes temperature-sensitive paralysis, shortened lifespan, and neurodegeneration.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables fructose-1-phosphate aldolase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables fructose-bisphosphate aldolase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables fructose-bisphosphate aldolase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables fructose-bisphosphate aldolase activity IEA
Inferred from Electronic Annotation
more info
  
enables fructose-bisphosphate aldolase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in canonical glycolysis IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in fructose 1,6-bisphosphate metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in fructose 1,6-bisphosphate metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in fructose catabolic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in gluconeogenesis ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in glucose homeostasis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in glyceraldehyde-3-phosphate metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in glycolytic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in glycolytic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in glycolytic process IEA
Inferred from Electronic Annotation
more info
  
involved_in mesoderm development NAS
Non-traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
located_in M band IDA
Inferred from Direct Assay
more info
 PubMed 
located_in Z disc IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol HDA PubMed 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
aldolase 1
Names
Ald1-PB
Ald1-PC
Ald1-PD
Ald1-PE
Ald1-PH
Ald1-PI
Ald1-PJ
Ald1-PK
Ald1-PL
Ald1-PM
CG6058-PB
CG6058-PC
CG6058-PD
CG6058-PE
CG6058-PH
CG6058-PI
CG6058-PJ
CG6058-PK
CG6058-PL
CG6058-PM
aldolase
fructose 1,6 biphosphate-aldolase A
NP_001262985.1
NP_001287541.1
NP_524515.2
NP_733140.2
NP_733141.1
NP_733142.1
NP_733143.1
NP_733144.3
NP_733145.3
NP_996300.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    26254069..26261591 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_170262.2 → NP_733141.1  aldolase 1, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_733141.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A4V3F9, A5XCY2, P07764, P29841, Q24236, Q24237, Q7KRY9, Q8IMS1, Q8MQQ4, Q9VBG2, Q9VBG3
    UniProtKB/TrEMBL
    C8VV14, F3YDB5
    Related
    FBpp0084367
    Conserved Domains (1) summary
    pfam00274
    Location:15 → 361
    Glycolytic; Fructose-bisphosphate aldolase class-I

  2. NM_001300612.1 → NP_001287541.1  aldolase 1, isoform M [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001287541.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A4V3F9, A5XCY2, P07764, P29841, Q24236, Q24237, Q7KRY9, Q8IMS1, Q8MQQ4, Q9VBG2, Q9VBG3
    UniProtKB/TrEMBL
    C8VV14, F3YDB5
    Conserved Domains (1) summary
    pfam00274
    Location:15 → 361
    Glycolytic; Fructose-bisphosphate aldolase class-I

  3. NM_170263.4 → NP_733142.1  aldolase 1, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_733142.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A4V3F9, A5XCY2, P07764, P29841, Q24236, Q24237, Q7KRY9, Q8IMS1, Q8MQQ4, Q9VBG2, Q9VBG3
    UniProtKB/TrEMBL
    C8VV14, F3YDB5
    Related
    FBpp0084368
    Conserved Domains (1) summary
    pfam00274
    Location:15 → 361
    Glycolytic; Fructose-bisphosphate aldolase class-I

  4. NM_170265.4 → NP_733144.3  aldolase 1, isoform K [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_733144.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A4V3F9, A5XCY2, P07764, P29841, Q24236, Q24237, Q7KRY9, Q8IMS1, Q8MQQ4, Q9VBG2, Q9VBG3
    UniProtKB/TrEMBL
    C8VV14, F3YDB5
    Conserved Domains (1) summary
    pfam00274
    Location:15 → 361
    Glycolytic; Fructose-bisphosphate aldolase class-I

  5. NM_170264.3 → NP_733143.1  aldolase 1, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_733143.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A4V3F9, A5XCY2, P07764, P29841, Q24236, Q24237, Q7KRY9, Q8IMS1, Q8MQQ4, Q9VBG2, Q9VBG3
    UniProtKB/TrEMBL
    C8VV14, F3YDB5
    Related
    FBpp0084372
    Conserved Domains (1) summary
    pfam00274
    Location:15 → 361
    Glycolytic; Fructose-bisphosphate aldolase class-I

  6. NM_001276056.1 → NP_001262985.1  aldolase 1, isoform L [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001262985.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    F3YDB5, F3YDE2
    Conserved Domains (1) summary
    pfam00274
    Location:15 → 363
    Glycolytic; Fructose-bisphosphate aldolase class-I

  7. NM_170261.3 → NP_733140.2  aldolase 1, isoform J [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_733140.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    F3YDB5, F3YDE2
    Conserved Domains (1) summary
    pfam00274
    Location:15 → 363
    Glycolytic; Fructose-bisphosphate aldolase class-I

  8. NM_206577.3 → NP_996300.1  aldolase 1, isoform H [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_996300.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    F3YDB5, F3YDE2
    Conserved Domains (1) summary
    pfam00274
    Location:15 → 363
    Glycolytic; Fructose-bisphosphate aldolase class-I

  9. NM_170266.4 → NP_733145.3  aldolase 1, isoform I [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_733145.3

    Status: REVIEWED

    UniProtKB/TrEMBL
    A4V3G1, F3YDB5
    Conserved Domains (1) summary
    pfam00274
    Location:15 → 363
    Glycolytic; Fructose-bisphosphate aldolase class-I

  10. NM_079791.5 → NP_524515.2  aldolase 1, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_524515.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    A4V3G1, F3YDB5
    Related
    FBpp0084373
    Conserved Domains (1) summary
    pfam00274
    Location:15 → 363
    Glycolytic; Fructose-bisphosphate aldolase class-I
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A4V3G1 A4V3G1
C8VV14 C8VV14
F3YDE2 F3YDE2
P07764.5 P07764
Q86NZ4 Q86NZ4

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