acta2.L actin, alpha 2, smooth muscle, aorta L homeolog [Xenopus laevis (African clawed frog)] - Gene

Summary

Official Symbol: acta2.L
Official Full Name: actin, alpha 2, smooth muscle, aorta L homeolog
Primary source: Xenbase:XB-GENE-866302
Locus tag: XELAEV_18034370mg
See related: EnsemblRapid:ENSXLAG00005036558 AllianceGenome:Xenbase:XB-GENE-866302
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Xenopus laevis
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as: sma; ASMA; aat6; a-sma; acta2; actsa; mymy5; SMactin; acta2.S; sm-actin; alpha-actin
Summary: Predicted to enable ATP binding activity and hydrolase activity. Predicted to act upstream of or within mesenchyme migration and positive regulation of gene expression. Predicted to be located in several cellular components, including cell body; filopodium; and lamellipodium. Is expressed in cardiovascular system; mesoderm; musculoskeletal system; and nervous system. Human ortholog(s) of this gene implicated in Moyamoya disease and thoracic aortic aneurysm. Orthologous to human ACTA2 (actin alpha 2, smooth muscle). [provided by Alliance of Genome Resources, Jan 2025]
Annotation information: Annotation category: partial on reference assembly
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Genomic context

Location:: chromosome: 7L

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
101	current	Xenopus_laevis_v10.1 (GCF_017654675.1)	7L	NC_054383.1 (6909529..6916681, complement)
100	previous assembly	Xenopus_laevis_v2 (GCF_001663975.1)	7L	NC_030736.1 (6935121..6942464, complement)

Chromosome 7L - NC_054383.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Data show that the locomotion and blebbing of the primordial germ cells (PGCs) required F-actin, myosin II activity and RhoA/Rho-associated protein kinase (ROCK) signaling.
Title: Developmental regulation of locomotive activity in Xenopus primordial germ cells.

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General gene information

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Markers

Acta1 (e-PCR), detects polymorphism
- UniSTS:141013

Gene Ontology Provided by Xenbase

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within mesenchyme migration	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within positive regulation of gene expression	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in cell body	ISS Inferred from Sequence or Structural Similarity more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in filopodium	ISS Inferred from Sequence or Structural Similarity more info
located_in lamellipodium	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: actin, alpha 2, smooth muscle, aorta L homeolog

Names: SM actin; actin, alpha 2, smooth muscle, aorta S homeolog; alpha smooth muscle actin; alpha-SM-actin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.