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Nil Nilkantha [ Drosophila melanogaster (fruit fly) ]

Gene ID: 43185, updated on 4-Jan-2025

Summary

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Official Symbol
Nilprovided by FlyBase
Official Full Name
Nilkanthaprovided by FlyBase
Primary source
FLYBASE:FBgn0039421
Locus tag
Dmel_CG6036
See related
AllianceGenome:FB:FBgn0039421
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG6036; Dmel\CG6036; PP2Cb
Summary
Predicted to enable protein serine/threonine phosphatase activity. Predicted to be involved in negative regulation of ERK1 and ERK2 cascade and negative regulation of stress-activated MAPK cascade. Predicted to be located in cytoplasm. Predicted to be active in cytosol and nucleus. Orthologous to human PPM1A (protein phosphatase, Mg2+/Mn2+ dependent 1A) and PPM1B (protein phosphatase, Mg2+/Mn2+ dependent 1B). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
all
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Genomic context

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See Nil in Genome Data Viewer
Location:
97A9-97A9; 3-90 cM
Exon count:
1
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (26344290..26345473, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (22170012..22171195, complement)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR42765 Neighboring gene oskyddad Neighboring gene pickpocket 15 Neighboring gene Aldolase 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Identification of phosphatases for Smad in the BMP/DPP pathway. Chen HB, et al. Genes Dev, 2006 Mar 15. PMID 16510868, Free PMC Article
  2. Alphabet, a Ser/Thr phosphatase of the protein phosphatase 2C family, negatively regulates RAS/MAPK signaling in Drosophila. Baril C, et al. Dev Biol, 2006 Jun 1. PMID 16600208
  3. A phosphoswitch at acinus-serine(437) controls autophagic responses to cadmium exposure and neurodegenerative stress. Nandi N, et al. Elife, 2022 Jan 17. PMID 35037620, Free PMC Article
  4. Transgenic Drosophila lines for LexA-dependent gene and growth regulation. Chang KR, et al. G3 (Bethesda), 2022 Mar 4. PMID 35100369, Free PMC Article
  5. Age-dependent chromosomal distribution of male-biased genes in Drosophila. Zhang YE, et al. Genome Res, 2010 Nov. PMID 20798392, Free PMC Article

See all (34) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables magnesium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables manganese ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein serine/threonine phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine phosphatase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in negative regulation of ERK1 and ERK2 cascade IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of stress-activated MAPK cascade IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein dephosphorylation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
nilkantha
Names
CG6036-PA
Nil-PA
NP_651472.2

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    26344290..26345473 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_143215.2 → NP_651472.2  nilkantha [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_651472.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0AND0, A0AND5, A0AND6, A0AND8, A0AND9, C0MIV8, C0MIW1, Q9VBF9
    Related
    FBpp0084399
    Conserved Domains (2) summary
    cd00143
    Location:27 → 277
    PP2Cc; Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence ...
    pfam07830
    Location:284 → 352
    PP2C_C; Protein serine/threonine phosphatase 2C, C-terminal domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VBF9 Q9VBF9

Gene LinkOut

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