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plum plum [ Drosophila melanogaster (fruit fly) ]

Gene ID: 43197, updated on 4-Jan-2025

Summary

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Official Symbol
plumprovided by FlyBase
Official Full Name
plumprovided by FlyBase
Primary source
FLYBASE:FBgn0039431
Locus tag
Dmel_CG6490
See related
AllianceGenome:FB:FBgn0039431
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG6490; CT20213; Dmel\CG6490; Plum
Summary
Predicted to enable cell adhesion molecule binding activity. Involved in negative regulation of synaptic assembly at neuromuscular junction and neuron remodeling. Located in axon and dendrite. Is expressed in brain; mushroom body; neuropil; and synaptic neuropil domain. Orthologous to human HMCN2 (hemicentin 2). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
all
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Genomic context

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See plum in Genome Data Viewer
Location:
97B4-97B9; 3-91 cM
Exon count:
11
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (26470078..26535217, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (22295800..22360939, complement)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR46083 Neighboring gene long non-coding RNA:CR45226 Neighboring gene long non-coding RNA:CR46084 Neighboring gene scribble Neighboring gene long non-coding RNA:CR44951

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Plum modulates Myoglianin and regulates synaptic function in D. melanogaster. Sahota VK, et al. Open Biol, 2023 Sep. PMID 37699519, Free PMC Article
  2. Drosophila noktochor regulates night sleep via a local mushroom body circuit. Draper IR, et al. iScience, 2024 Mar 15. PMID 38380256, Free PMC Article
  3. Glial Derived TGF-β Instructs Axon Midline Stopping. Marmor-Kollet N, et al. Front Mol Neurosci, 2019. PMID 31611773, Free PMC Article
  4. A unique cluster of roo insertions in the promoter region of a stress response gene in Drosophila melanogaster. Merenciano M, et al. Mob DNA, 2019. PMID 30911338, Free PMC Article
  5. Plum, an immunoglobulin superfamily protein, regulates axon pruning by facilitating TGF-β signaling. Yu XM, et al. Neuron, 2013 May 8. PMID 23664613, Free PMC Article

See all (48) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Plum modulates Myoglianin and regulates synaptic function in D. melanogaster.
    Title: Plum modulates Myoglianin and regulates synaptic function in D. melanogaster.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables cell adhesion molecule binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in cell-cell adhesion IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of synaptic assembly at neuromuscular junction IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in neuron remodeling IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in axon IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cell-cell junction IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in dendrite IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
plum
Names
CG6490-PB
CG6490-PC
CG6490-PD
CG6490-PE
plum-PB
plum-PC
plum-PD
plum-PE

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    26470078..26535217 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001260388.1 → NP_001247317.1  plum, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001247317.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    C4XVK2, H5ZV05, Q9VBE5
    Conserved Domains (4) summary
    smart00408
    Location:378 → 435
    IGc2; Immunoglobulin C-2 Type
    smart00410
    Location:284 → 356
    IG_like; Immunoglobulin like
    cd00063
    Location:804 → 886
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam07679
    Location:360 → 443
    I-set; Immunoglobulin I-set domain

  2. NM_001170273.2 → NP_001163744.1  plum, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001163744.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    C4XVK2, H5ZV05, Q9VBE5
    Conserved Domains (4) summary
    smart00408
    Location:378 → 435
    IGc2; Immunoglobulin C-2 Type
    smart00410
    Location:284 → 356
    IG_like; Immunoglobulin like
    cd00063
    Location:804 → 886
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam07679
    Location:360 → 443
    I-set; Immunoglobulin I-set domain

  3. NM_143225.3 → NP_651482.3  plum, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_651482.3

    Status: REVIEWED

    UniProtKB/TrEMBL
    C4XVK2, H5ZV05, Q9VBE5
    Conserved Domains (4) summary
    smart00408
    Location:378 → 435
    IGc2; Immunoglobulin C-2 Type
    smart00410
    Location:284 → 356
    IG_like; Immunoglobulin like
    cd00063
    Location:804 → 886
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam07679
    Location:360 → 443
    I-set; Immunoglobulin I-set domain

  4. NM_001300615.1 → NP_001287544.1  plum, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001287544.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    C4XVK2, H5ZV05, Q9VBE5
    Conserved Domains (4) summary
    smart00408
    Location:378 → 435
    IGc2; Immunoglobulin C-2 Type
    smart00410
    Location:284 → 356
    IG_like; Immunoglobulin like
    cd00063
    Location:804 → 886
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam07679
    Location:360 → 443
    I-set; Immunoglobulin I-set domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8T986 Q8T986
Q9VBE5 Q9VBE5

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