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TwdlB TweedleB [ Drosophila melanogaster (fruit fly) ]

Gene ID: 43202, updated on 9-Dec-2024

Summary

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Official Symbol
TwdlBprovided by FlyBase
Official Full Name
TweedleBprovided by FlyBase
Primary source
FLYBASE:FBgn0039436
Locus tag
Dmel_CG6478
See related
AllianceGenome:FB:FBgn0039436
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG6478; Dmel\CG6478
Summary
Predicted to be a structural constituent of chitin-based larval cuticle. Predicted to be involved in body morphogenesis and chitin-based cuticle development. Predicted to be located in extracellular matrix. Predicted to be active in chitin-based extracellular matrix. Is expressed in embryonic dorsal epidermis and embryonic ventral epidermis. [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See TwdlB in Genome Data Viewer
Location:
97C2-97C2; 3-91 cM
Exon count:
2
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (26622451..26623543, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (22448173..22449265, complement)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene TweedleM Neighboring gene TweedleP Neighboring gene TweedleL Neighboring gene TweedleO

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. MOD(MDG4)-64.2 protein, isoform of MOD(MDG4) loci, directly interacts with the Tweedle protein family of Drosophila melanogaster. Golovnin AK, et al. Dokl Biochem Biophys, 2013 Sep. PMID 24150578
  2. Mutation of TweedleD, a member of an unconventional cuticle protein family, alters body shape in Drosophila. Guan X, et al. Proc Natl Acad Sci U S A, 2006 Nov 7. PMID 17075064, Free PMC Article
  3. FGF ligands in Drosophila have distinct activities required to support cell migration and differentiation. Kadam S, et al. Development, 2009 Mar. PMID 19158183, Free PMC Article
  4. The distribution of GYR- and YLP-like motifs in Drosophila suggests a general role in cuticle assembly and other protein-protein interactions. Cornman RS. PLoS One, 2010 Sep 2. PMID 20824096, Free PMC Article
  5. Transcriptomic Insights into the Insect Immune Response to Nematode Infection. Eleftherianos I, et al. Genes (Basel), 2021 Jan 30. PMID 33573306, Free PMC Article

See all (30) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables structural constituent of chitin-based cuticle ISS
Inferred from Sequence or Structural Similarity
more info
  
enables structural constituent of chitin-based larval cuticle IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in body morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in chitin-based cuticle development IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in chitin-based cuticle development ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
is_active_in chitin-based extracellular matrix IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in extracellular matrix ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
TweedleB
Names
CG6478-PA
TwdlB-PA
tweedle
tweedle B

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    26622451..26623543 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_143229.2 → NP_651486.1  TweedleB [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_651486.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8SXS1, Q9VBE0
    Related
    FBpp0084429
    Conserved Domains (1) summary
    smart00690
    Location:122 → 223
    DM5; Domain of unknown function, currently peculiar to Drosophila
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8SXS1 Q8SXS1
Q9VBE0 Q9VBE0

Gene LinkOut

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