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TwdlH TweedleH [ Drosophila melanogaster (fruit fly) ]

Gene ID: 43208, updated on 9-Dec-2024

Summary

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Official Symbol
TwdlHprovided by FlyBase
Official Full Name
TweedleHprovided by FlyBase
Primary source
FLYBASE:FBgn0051080
Locus tag
Dmel_CG31080
See related
AllianceGenome:FB:FBgn0051080
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG14241; CG31080; Dmel\CG31080
Summary
A structural constituent of chitin-based larval cuticle. Involved in chitin-based cuticle development. Located in chitin-based extracellular matrix. [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See TwdlH in Genome Data Viewer
Location:
97C2-97C2; 3-91 cM
Exon count:
2
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (26633732..26634714)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (22459454..22460436)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene TweedleJ Neighboring gene TweedleN Neighboring gene TweedleR Neighboring gene TweedleS

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Mutation of TweedleD, a member of an unconventional cuticle protein family, alters body shape in Drosophila. Guan X, et al. Proc Natl Acad Sci U S A, 2006 Nov 7. PMID 17075064, Free PMC Article
  2. The distribution of GYR- and YLP-like motifs in Drosophila suggests a general role in cuticle assembly and other protein-protein interactions. Cornman RS. PLoS One, 2010 Sep 2. PMID 20824096, Free PMC Article
  3. Transcriptomic Insights into the Insect Immune Response to Nematode Infection. Eleftherianos I, et al. Genes (Basel), 2021 Jan 30. PMID 33573306, Free PMC Article
  4. Annotation and analysis of low-complexity protein families of Anopheles gambiae that are associated with cuticle. Cornman RS, et al. Insect Mol Biol, 2009 Oct. PMID 19754739, Free PMC Article
  5. Molecular evolution of Drosophila cuticular protein genes. Cornman RS. PLoS One, 2009 Dec 17. PMID 20019874, Free PMC Article

See all (27) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables structural constituent of chitin-based larval cuticle IBA
Inferred from Biological aspect of Ancestor
more info
  
enables structural constituent of chitin-based larval cuticle IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in chitin-based cuticle development IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in chitin-based cuticle development IEP
Inferred from Expression Pattern
more info
 PubMed 
Component Evidence Code Pubs
is_active_in chitin-based extracellular matrix IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in chitin-based extracellular matrix IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
TweedleH
Names
CG31080-PA
TwdlH-PA
tweedle

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    26633732..26634714
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_143233.3 → NP_651490.1  TweedleH [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_651490.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8SZR0, Q9VBD4
    Related
    FBpp0084404
    Conserved Domains (1) summary
    smart00690
    Location:77 → 178
    DM5; Domain of unknown function, currently peculiar to Drosophila
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VBD4 Q9VBD4

Gene LinkOut

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