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amon amontillado [ Drosophila melanogaster (fruit fly) ]

Gene ID: 43215, updated on 4-Jan-2025

Summary

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Official Symbol
amonprovided by FlyBase
Official Full Name
amontilladoprovided by FlyBase
Primary source
FLYBASE:FBgn0023179
Locus tag
Dmel_CG6438
See related
AllianceGenome:FB:FBgn0023179
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
Amon; CG6438; Dmel\CG6438; DMH#5; dPC2; PC2; Ppp; PPP
Summary
Enables peptidase activity. Involved in several processes, including R8 cell fate specification; hatching behavior; and larval wandering behavior. Located in extracellular region. Is expressed in several structures, including adult head; ganglia; gut section; larval CNS neuron; and presumptive embryonic/larval system. Human ortholog(s) of this gene implicated in myocardial infarction and type 2 diabetes mellitus. Orthologous to human PCSK2 (proprotein convertase subtilisin/kexin type 2). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

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See amon in Genome Data Viewer
Location:
97C4-97C5; 3-91 cM
Exon count:
12
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (26697697..26714159, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (22523419..22539881, complement)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene beaten path VII Neighboring gene Tubby Neighboring gene TweedleQ Neighboring gene uncharacterized protein Neighboring gene Yip1-interacting factor 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Interaction of Drosophila melanogaster prohormone convertase 2 and 7B2. Insect cell-specific processing and secretion. Hwang JR, et al. J Biol Chem, 2000 Jun 9. PMID 10749852
  2. The proprotein convertase encoded by amontillado (amon) is required in Drosophila corpora cardiaca endocrine cells producing the glucose regulatory hormone AKH. Rhea JM, et al. PLoS Genet, 2010 May 27. PMID 20523747, Free PMC Article
  3. amontillado, the Drosophila homolog of the prohormone processing protease PC2, is required during embryogenesis and early larval development. Rayburn LY, et al. Genetics, 2003 Jan. PMID 12586710, Free PMC Article
  4. A role for amontillado, the Drosophila homolog of the neuropeptide precursor processing protease PC2, in triggering hatching behavior. Siekhaus DE, et al. J Neurosci, 1999 Aug 15. PMID 10436051, Free PMC Article
  5. The proprotein convertase amontillado (amon) is required during Drosophila pupal development. Rayburn LY, et al. Dev Biol, 2009 Sep 1. PMID 19559693, Free PMC Article

See all (77) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. our findings provide the first direct evidence that AMON is a key enzyme in the production of neuropeptides in the fruitfly
    Title: Deficiency of prohormone convertase dPC2 (AMONTILLADO) results in impaired production of bioactive neuropeptide hormones in Drosophila.
  2. amon is required for pupal development and identify a subset of neuronal cell types in which amon function is sufficient to rescue developmental progression and growth defects shown by amon mutants.
    Title: The proprotein convertase amontillado (amon) is required during Drosophila pupal development.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables peptidase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables serine hydrolase activity HDA PubMed 
enables serine-type endopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables serine-type endopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in R8 cell fate specification IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in carbohydrate homeostasis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in hatching behavior IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in instar larval or pupal development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in larval wandering behavior IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in peptide hormone processing IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in peptide hormone processing IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in proteolysis IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in extracellular region IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in neuron projection IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
amontillado
Names
CG6438-PA
amon-PA
prohormone processing protease
NP_477318.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    26697697..26714159 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_057970.4 → NP_477318.1  amontillado [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_477318.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9UAE7, Q9VBC7
    Related
    FBpp0084420
    Conserved Domains (5) summary
    cd04059
    Location:150 → 446
    Peptidases_S8_Protein_convertases_Kexins_Furin-like; Peptidase S8 family domain in Protein convertases
    pfam00082
    Location:187 → 459
    Peptidase_S8; Subtilase family
    pfam01483
    Location:534 → 621
    P_proprotein; Proprotein convertase P-domain
    pfam16470
    Location:43 → 122
    S8_pro-domain; Peptidase S8 pro-domain
    cl10459
    Location:409 → 485
    Peptidases_S8_S53; Peptidase domain in the S8 and S53 families
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VBC7.1 Q9VBC7

Gene LinkOut

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