gstt1.L glutathione S-transferase theta 1 L homeolog [Xenopus laevis (African clawed frog)] - Gene

Summary

Official Symbol: gstt1.L
Official Full Name: glutathione S-transferase theta 1 L homeolog
Primary source: Xenbase:XB-GENE-998701
Locus tag: XELAEV_18007619mg
See related: AllianceGenome:Xenbase:XB-GENE-998701
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Xenopus laevis
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as: gstt1
Summary: Predicted to enable glutathione transferase activity. Predicted to be located in cytoplasm. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); cancer (multiple); cardiovascular system disease (multiple); eye disease (multiple); and lung disease (multiple). Orthologous to human GSTT1 (glutathione S-transferase theta 1). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

Location:: chromosome: 1L

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
101	current	Xenopus_laevis_v10.1 (GCF_017654675.1)	1L	NC_054371.1 (165848311..165861036, complement)
100	previous assembly	Xenopus_laevis_v2 (GCF_001663975.1)	1L	NC_030724.1 (152766349..152779109, complement)

Chromosome 1L - NC_054371.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by Xenbase

Function	Evidence Code	Pubs
enables glutathione transferase activity	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: glutathione S-transferase theta 1 L homeolog

NP_001085203.1

EC 2.5.1.18

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001091734.1 → NP_001085203.1 glutathione S-transferase theta 1 L homeolog

See identical proteins and their annotated locations for NP_001085203.1

Status: PROVISIONAL

Source sequence(s)

BC072203

UniProtKB/TrEMBL

A0A974I579, Q6INS0

Conserved Domains (3) summary

cd03183
Location:92 → 217

GST_C_Theta; C-terminal, alpha helical domain of Class Theta Glutathione S-transferases

COG0625
Location:4 → 214

GstA; Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]

cd03050
Location:4 → 79

GST_N_Theta; GST_N family, Class Theta subfamily; composed of eukaryotic class Theta GSTs and bacterial dichloromethane (DCM) dehalogenase. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with ...

RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Xenopus_laevis_v10.1 Primary Assembly

Genomic

NC_054371.1 Reference Xenopus_laevis_v10.1 Primary Assembly

Range

165848311..165861036 complement

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GenBank, FASTA, Sequence Viewer (Graphics)