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SPARC Secreted protein, acidic, cysteine-rich [ Drosophila melanogaster (fruit fly) ]

Gene ID: 43230, updated on 4-Jan-2025

Summary

Official Symbol
SPARCprovided by FlyBase
Official Full Name
Secreted protein, acidic, cysteine-richprovided by FlyBase
Primary source
FLYBASE:FBgn0026562
Locus tag
Dmel_CG6378
See related
AllianceGenome:FB:FBgn0026562
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
anon-EST:Posey291; BM-40 Sparc; BM-40-SPARC; BM-40/SPARC; BM40; CG6378; CT19876; Dmel\CG6378; dsparc; dSparc; dSPARC; sparc; Sparc
Summary
Predicted to enable calcium ion binding activity; collagen binding activity; and extracellular matrix binding activity. Involved in several processes, including Malpighian tubule development; extracellular matrix organization; and larval fat body development. Located in extracellular space. Is expressed in several structures, including CNS glial cell; embryonic/larval hemocyte; embryonic/larval midgut primordium; ganglia; and germ layer. Used to study cardiomyopathy. Human ortholog(s) of this gene implicated in cervix carcinoma; endometrial carcinoma; multiple myeloma; and osteogenesis imperfecta type 17. Orthologous to several human genes including SPARC (secreted protein acidic and cysteine rich). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

See SPARC in Genome Data Viewer
Location:
97D3-97D3; 3-92 cM
Exon count:
4
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (26869238..26871995, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (22694960..22697717, complement)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene ballchen Neighboring gene Histone H2A variant Neighboring gene Ribonuclear protein at 97D Neighboring gene male sterile (3) K81

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables calcium ion binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
 
enables collagen binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables extracellular matrix binding IBA
Inferred from Biological aspect of Ancestor
more info
 
Process Evidence Code Pubs
involved_in Malpighian tubule morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in anterior Malpighian tubule development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in basement membrane assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cell adhesion ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
involved_in extracellular matrix constituent secretion IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in larval fat body development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in larval feeding behavior IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in mesoderm development IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in trachea development IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in collagen-containing extracellular matrix HDA PubMed 
located_in extracellular matrix ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
located_in extracellular space IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
secreted protein, acidic, cysteine-rich
Names
BM-40-SPARC
BM-40-secreted protein acidic and rich in cysteine
CG6378-PA
CG6378-PB
SPARC-PA
SPARC-PB
osteonectin

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    26869238..26871995 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_143252.4NP_651509.2  secreted protein, acidic, cysteine-rich, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_651509.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    O97365, Q8SY75, Q9VBB0
    Related
    FBpp0084464
    Conserved Domains (3) summary
    cd00252
    Location:170292
    SPARC_EC; SPARC_EC; extracellular Ca2+ binding domain (containing 2 EF-hand motifs) of SPARC and related proteins (QR1, SC1/hevin, testican and tsc-36/FRP). SPARC (BM-40) is a multifunctional glycoprotein, a matricellular protein, that functions to regulate ...
    cd01328
    Location:85168
    FSL_SPARC; Follistatin-like SPARC (secreted protein, acidic, and rich in cysteines) domain; SPARC/BM-40/osteonectin is a multifunctional glycoprotein which modulates cellular interaction with the extracellular matrix by its binding to structural matrix proteins ...
    pfam10591
    Location:169278
    SPARC_Ca_bdg; Secreted protein acidic and rich in cysteine Ca binding region
  2. NM_001276069.1NP_001262998.1  secreted protein, acidic, cysteine-rich, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001262998.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    O97365, Q8SY75, Q9VBB0
    Conserved Domains (3) summary
    cd00252
    Location:170292
    SPARC_EC; SPARC_EC; extracellular Ca2+ binding domain (containing 2 EF-hand motifs) of SPARC and related proteins (QR1, SC1/hevin, testican and tsc-36/FRP). SPARC (BM-40) is a multifunctional glycoprotein, a matricellular protein, that functions to regulate ...
    cd01328
    Location:85168
    FSL_SPARC; Follistatin-like SPARC (secreted protein, acidic, and rich in cysteines) domain; SPARC/BM-40/osteonectin is a multifunctional glycoprotein which modulates cellular interaction with the extracellular matrix by its binding to structural matrix proteins ...
    pfam10591
    Location:169278
    SPARC_Ca_bdg; Secreted protein acidic and rich in cysteine Ca binding region