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Ets97D Ets at 97D [ Drosophila melanogaster (fruit fly) ]

Gene ID: 43236, updated on 9-Dec-2024

Summary

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Official Symbol
Ets97Dprovided by FlyBase
Official Full Name
Ets at 97Dprovided by FlyBase
Primary source
FLYBASE:FBgn0004510
Locus tag
Dmel_CG6338
See related
AllianceGenome:FB:FBgn0004510
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG6338; d-elg; D-elg; D-Elg; delg; Delg; DELG; Dmel\CG6338; elg; Elg; Ets; tne; tny
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific. Involved in several processes, including positive regulation of oxidative phosphorylation; positive regulation of transcription by RNA polymerase II; and regulation of glutamine family amino acid metabolic process. Predicted to be active in nucleus. Is expressed in organism; posterior midgut primordium; and primordial germ cell. Orthologous to human GABPA (GA binding protein transcription factor subunit alpha). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
all
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Genomic context

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See Ets97D in Genome Data Viewer
Location:
97D7-97D7; 3-92 cM
Exon count:
5
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (26910775..26912886, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (22736497..22738608, complement)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene male sterile (3) K81 Neighboring gene uncharacterized protein Neighboring gene rough Neighboring gene Transcript 48 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Molecular characterization and structural organization of D-elg, an ets proto-oncogene-related gene of Drosophila. The SM, et al. Oncogene, 1992 Dec. PMID 1461651
  2. Ets oncogene-related gene Elg functions in Drosophila oogenesis. Schulz RA, et al. Proc Natl Acad Sci U S A, 1993 Nov 1. PMID 8234259, Free PMC Article
  3. A cis-regulatory element promoting increased transcription at low temperature in cultured ectothermic Drosophila cells. Bai Y, et al. BMC Genomics, 2021 Oct 28. PMID 34711176, Free PMC Article
  4. D-elg, a member of the Drosophila ets gene family: sequence, expression and evolutionary comparison. Pribyl LJ, et al. Oncogene, 1991 Jul. PMID 1713660
  5. The yan gene is highly conserved in Drosophila and its expression suggests a complex role throughout development. Price MD, et al. Dev Genes Evol, 1999 Apr. PMID 10079364

See all (67) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Delg and cyclin D/Cdk4 have roles in nutritional control of mitochondrial biogenesis in the Drosophila adipose tissue
    Title: Nutrition controls mitochondrial biogenesis in the Drosophila adipose tissue through Delg and cyclin D/Cdk4.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables DNA-binding transcription factor activity IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cellular response to starvation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of oxidative phosphorylation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of glutamine family amino acid metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of mitochondrion organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Ets at 97D
Names
CG6338-PA
CG6338-PB
Ets like gene
Ets97D-PA
Ets97D-PB
tiny
tiny eggs

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    26910775..26912886 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_079799.3 → NP_524523.2  Ets at 97D, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_524523.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q04688, Q1LZ02, Q8SZC7, Q9VBA4
    Related
    FBpp0084458
    Conserved Domains (3) summary
    cd08534
    Location:184 → 272
    SAM_PNT-GABP-alpha; Sterile alpha motif (SAM)/Pointed domain of GA-binding protein (GABP) alpha chain
    smart00413
    Location:345 → 429
    ETS; erythroblast transformation specific domain
    pfam11620
    Location:48 → 123
    GABP-alpha; GA-binding protein alpha chain

  2. NM_001276071.1 → NP_001263000.1  Ets at 97D, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001263000.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4KHY6
    Conserved Domains (3) summary
    cd08534
    Location:184 → 272
    SAM_PNT-GABP-alpha; Sterile alpha motif (SAM)/Pointed domain of GA-binding protein (GABP) alpha chain
    smart00413
    Location:345 → 429
    ETS; erythroblast transformation specific domain
    pfam11620
    Location:48 → 123
    GABP-alpha; GA-binding protein alpha chain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A0B4KHY6 A0A0B4KHY6
Q04688.2 Q04688

Gene LinkOut

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