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SNAI2 snail family transcriptional repressor 2 [ Gallus gallus (chicken) ]

Gene ID: 432368, updated on 17-Aug-2024

Summary

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Symbol
SNAI2provided by CGNC
Full Name
snail family transcriptional repressor 2provided by CGNC
Primary source
CGNC:54314
See related
Ensembl:ENSGALG00010005487
Gene type
protein coding
RefSeq status
MODEL
Organism
Gallus gallus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Orthologs
human mouse all
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Genomic context

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See SNAI2 in Genome Data Viewer
Location:
chromosome: 2
Exon count:
3
Annotation release Status Assembly Chr Location
106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 2 NC_052533.1 (108099701..108103167, complement)
106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 2 NC_052574.1 (108165134..108168600, complement)

Chromosome 2 - NC_052533.1Genomic Context describing neighboring genes Neighboring gene U6 spliceosomal RNA Neighboring gene uncharacterized LOC107052711 Neighboring gene uncharacterized LOC124417696 Neighboring gene C8orf22 homolog

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Novel insight into the function and regulation of alphaN-catenin by Snail2 during chick neural crest cell migration. Jhingory S, et al. Dev Biol, 2010 Aug 15. PMID 20542025, Free PMC Article
  2. Control of cell behavior during vertebrate development by Slug, a zinc finger gene. Nieto MA, et al. Science, 1994 May 6. PMID 7513443
  3. Snail2 and Zeb2 repress P-cadherin to define embryonic territories in the chick embryo. Acloque H, et al. Development, 2017 Feb 15. PMID 28087626
  4. Snail2 directly represses cadherin6B during epithelial-to-mesenchymal transitions of the neural crest. Taneyhill LA, et al. Development, 2007 Apr. PMID 17344227, Free PMC Article
  5. Expression of chicken slug and snail in mesenchymal components of the developing central nervous system. Marin F, et al. Dev Dyn, 2004 May. PMID 15108319

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Alcohol-mediated calcium signals dysregulate pro-survival Snai2/PUMA/Bcl2 networks to promote p53-mediated apoptosis in avian neural crest progenitors.
    Title: Alcohol-mediated calcium signals dysregulate pro-survival Snai2/PUMA/Bcl2 networks to promote p53-mediated apoptosis in avian neural crest progenitors.
  2. Snail1/E-cadherin axis described in the early mouse embryo corresponds to Snail2/P-cadherin in the chick, but both Snail factors and Zeb2 fulfil a similar role in chick and mouse in directly repressing ectodermal cadherin genes to contribute to the delamination of mesendodermal precursors at gastrulation and the proper specification of the neural ectoderm during neural induction
    Title: Snail2 and Zeb2 repress P-cadherin to define embryonic territories in the chick embryo.
  3. Novel insight into the function and regulation of alphaN-catenin by SNAIL2 during chick neural crest cell migration is reported.
    Title: Novel insight into the function and regulation of alphaN-catenin by Snail2 during chick neural crest cell migration.
  4. Slug is expressed in the meninges and in the pericytes/vascular smooth muscle cells of the brain, the spinal cord and other embryonic tissues; snail is expressed in the stroma of the choroid plexus of both the developmng hindbrain and the forebrain
    Title: Expression of chicken slug and snail in mesenchymal components of the developing central nervous system.
  5. Results report the cyclic mRNA expression of Snail 1 and Snail 2 in the mouse and chick presomitic mesoderm (PSM), respectively.
    Title: Oscillations of the snail genes in the presomitic mesoderm coordinate segmental patterning and morphogenesis in vertebrate somitogenesis.
  6. Cadherin6B is a direct target of Snail2 repression in vivo and in the context of the EMT that characterizes neural crest development.
    Title: Snail2 directly represses cadherin6B during epithelial-to-mesenchymal transitions of the neural crest.
  7. expression in the cranial neural crest of the early embryo (Slug; HNK-1)
    Title: Relative expression of Slug, RhoB, and HNK-1 in the cranial neural crest of the early chicken embryo.
Submit: New GeneRIF Correction

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
zinc finger protein SNAI2
Names
slug
snail family zinc finger 2
snail homolog 2

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

  1. NC_052533.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Range
    108099701..108103167 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_419196.8 → XP_419196.3  zinc finger protein SNAI2 isoform X1

    UniProtKB/TrEMBL
    A0A8V0XHQ3
    Related
    ENSGALP00010007668.1, ENSGALT00010013106.1
    Conserved Domains (5) summary
    COG5189
    Location:101 → 182
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    sd00017
    Location:187 → 207
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:130 → 150
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:213 → 235
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:200 → 223
    zf-H2C2_2; Zinc-finger double domain

  2. XM_046932391.1 → XP_046788347.1  zinc finger protein SNAI2 isoform X2

    UniProtKB/TrEMBL
    A0A8V0XLU8
    Related
    ENSGALP00010007667.1, ENSGALT00010013105.1

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

  1. NC_052574.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Range
    108165134..108168600 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_040664699.2 → XP_040520633.1  zinc finger protein SNAI2 isoform X1

    UniProtKB/TrEMBL
    A0A8V0XHQ3
    Conserved Domains (5) summary
    COG5189
    Location:101 → 182
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    sd00017
    Location:187 → 207
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:130 → 150
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:213 → 235
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:200 → 223
    zf-H2C2_2; Zinc-finger double domain

  2. XM_046911884.1 → XP_046767840.1  zinc finger protein SNAI2 isoform X2

    UniProtKB/TrEMBL
    A0A8V0XLU8
Nucleotide Protein Strain
Heading Accession and Version

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