U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

CG6051 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

Gene ID: 43271, updated on 9-Dec-2024

Summary

Go to the top of the page Help
Official Symbol
CG6051provided by FlyBase
Official Full Name
uncharacterized proteinprovided by FlyBase
Primary source
FLYBASE:FBgn0039492
Locus tag
Dmel_CG6051
See related
AllianceGenome:FB:FBgn0039492
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
blr2; Dmel\CG6051
Summary
Predicted to enable metal ion binding activity. Predicted to be involved in negative regulation of epidermal growth factor receptor signaling pathway. Predicted to be active in early endosome membrane. Is expressed in several structures, including embryonic hypopharynx; embryonic proventriculus inner layer; embryonic/larval midgut primordium; embryonic/larval posterior spiracle; and gut section. Orthologous to human ZFYVE28 (zinc finger FYVE-type containing 28). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See CG6051 in Genome Data Viewer
Location:
97E3-97E5; 3-92 cM
Exon count:
5
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (27124759..27151069, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (22950481..22976791, complement)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Malic enzyme b Neighboring gene Gram-positive Specific Serine protease

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Class III phosphatidylinositol-3-OH kinase controls epithelial integrity through endosomal LKB1 regulation. O'Farrell F, et al. Nat Cell Biol, 2017 Dec. PMID 29084199
  2. Integrative genomic analysis reveals novel regulatory mechanisms of eyeless during Drosophila eye development. Yeung K, et al. Nucleic Acids Res, 2018 Dec 14. PMID 30295802, Free PMC Article
  3. Identification of circadian-clock-regulated enhancers and genes of Drosophila melanogaster by transposon mobilization and luciferase reporting of cyclical gene expression. Stempfl T, et al. Genetics, 2002 Feb. PMID 11861563, Free PMC Article
  4. The nucleosome remodeling factor ISWI functionally interacts with an evolutionarily conserved network of cellular factors. Arancio W, et al. Genetics, 2010 May. PMID 20194965, Free PMC Article
  5. A comparative genomic analysis of two distant diptera, the fruit fly, Drosophila melanogaster, and the malaria mosquito, Anopheles gambiae. Bolshakov VN, et al. Genome Res, 2002 Jan. PMID 11779831, Free PMC Article

See all (29) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in negative regulation of epidermal growth factor receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in early endosome membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

Go to the top of the page Help
Preferred Names
uncharacterized protein
Names
CG6051-PB
CG6051-PC
CG6051-PD
blade runner 2

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    27124759..27151069 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001300627.1 → NP_001287556.1  uncharacterized protein Dmel_CG6051, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001287556.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4LHZ6
    Conserved Domains (1) summary
    cd15731
    Location:901 → 965
    FYVE_LST2; FYVE domain found in lateral signaling target protein 2 homolog (Lst2) and similar proteins

  2. NM_001260396.1 → NP_001247325.1  uncharacterized protein Dmel_CG6051, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001247325.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q86P84, Q8T0G9, Q9VB70
    UniProtKB/TrEMBL
    A0A0B4K6M9
    Conserved Domains (1) summary
    cd15731
    Location:902 → 966
    FYVE_LST2; FYVE domain found in lateral signaling target protein 2 homolog (Lst2) and similar proteins

  3. NM_001104473.2 → NP_001097943.1  uncharacterized protein Dmel_CG6051, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001097943.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q86P84, Q8T0G9, Q9VB70
    UniProtKB/TrEMBL
    A0A0B4K6M9
    Conserved Domains (1) summary
    cd15731
    Location:902 → 966
    FYVE_LST2; FYVE domain found in lateral signaling target protein 2 homolog (Lst2) and similar proteins
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A0B4K6M9 A0A0B4K6M9
A0A0B4LHZ6 A0A0B4LHZ6
Q9VB70.3 Q9VB70

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Other Literature Sources
Chemical Information
Molecular Biology Databases
Research Materials
Tools